{"id":"W4323351021","doi":"10.1093/jcag/gwac036.039","title":"A39 HEALTHY FIRST-DEGREE RELATIVES FROM MULTIPLEX FAMILIES VERSUS SIMPLEX HARBOR A HIGHER RISK OF DEVELOPING CROHN'S DISEASE AND ARE ASSOCIATED WITH SUBCLINICAL INFLAMMATION AND ALTERED MICROBIOME COMPOSITION","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Ottawa; Hôpital Maisonneuve-Rosemont; BC Children's Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children; Children's Hospital of Eastern Ontario; University of Calgary; University of Alberta","funders":"","keywords":"Microbiome; Calprotectin; Subclinical infection; Multiplex; Cohort; Prospective cohort study; Immunology; Crohn's disease; Medicine; Disease; Internal medicine; Biology; Inflammatory bowel disease; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002911007,0.0005065796,0.0005117079,0.000811272,0.0007940975,0.0005646196,0.0002067713,0.000391593,0.008669033],"category_scores_gemma":[0.00123803,0.0002216992,0.0004518636,0.0007276484,0.0002276955,0.0002567006,0.0004555903,0.0002394085,0.0005737601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002216739,"about_ca_system_score_gemma":0.0001640997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00228189,"about_ca_topic_score_gemma":0.001909655,"domain_scores_codex":[0.9996964,0.00005406149,0.00003462071,0.0001243157,0.00004344962,0.00004705615],"domain_scores_gemma":[0.9995871,0.00008625504,0.000159957,0.00005292842,0.00002490873,0.00008883959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001539646,0.0001311441,0.9876804,0.00005286318,0.0001584877,0.001385124,0.0002085781,0.00006139264,0.003192945,0.00008528468,0.0003537901,0.005150243],"study_design_scores_gemma":[0.00004923723,0.000396945,0.9934868,0.00002469653,0.0001383419,0.003972115,0.0003549365,0.0002449123,0.0005083557,0.0001377742,0.0006757287,0.00001017591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990496,0.000168272,0.0001411688,0.00001680329,0.000005921427,0.00000852036,0.0003750453,0.000006723615,0.0002280085],"genre_scores_gemma":[0.9990119,0.00007066483,0.0001493645,0.0000162573,0.000008546649,0.0000152623,0.0003600397,0.000002817384,0.0003651911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008669033,"threshold_uncertainty_score":0.02900076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771699413661615,"score_gpt":0.2406810335373609,"score_spread":0.2229640394007448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}