{"id":"W4323351089","doi":"10.1093/jcag/gwac036.046","title":"A46 ENTEROBACTERIACEAE ENRICHMENT IN THE GUT MICROBIOME OF CRITICALLY ILL PATIENTS PROMOTES IMMUNE DYSFUNCTION AND SUSCEPTIBILITY TO NOSOCOMIAL INFECTIONS","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Government of Alberta","keywords":"Critically ill; Microbiome; Gut microbiome; Government (linguistics); Immune system; Immune Dysfunction; Immunology; Enterobacteriaceae; Medicine; Intensive care medicine; Biology; Microbiology; Political science; Bioinformatics; Genetics; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187163,0.0001762457,0.0002591434,0.0003533269,0.0003988185,0.0008022732,0.00009777654,0.0003610405,0.008153364],"category_scores_gemma":[0.00117324,0.0001268927,0.0002884755,0.0004640726,0.000162237,0.0002602527,0.0003541344,0.0003819764,0.0007731108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756678,"about_ca_system_score_gemma":0.0004157103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004607809,"about_ca_topic_score_gemma":0.004159529,"domain_scores_codex":[0.9997757,0.00004707586,0.00002384888,0.00003964729,0.00004612735,0.00006764496],"domain_scores_gemma":[0.9995384,0.00006903693,0.0001525725,0.00002127267,0.0001057844,0.0001129299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001962242,0.0001917905,0.9026289,0.0003389249,0.0002088265,0.0009147892,0.0005295945,0.0001346369,0.05179783,0.0001911317,0.006853135,0.0342481],"study_design_scores_gemma":[0.00001679224,0.0001639675,0.9932112,0.00009894162,0.00006443917,0.00092291,0.0007673769,0.0001344057,0.001588032,0.0001317747,0.002890919,0.000009156116],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935979,0.001584605,0.0002254971,0.0005286377,0.000103304,0.00001373486,0.001571534,0.00001752206,0.002357262],"genre_scores_gemma":[0.9962329,0.0008943967,0.0003896863,0.0003591128,0.00005563696,0.000009592548,0.00080672,0.00001401612,0.00123795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008153364,"threshold_uncertainty_score":0.02727568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022335334518747,"score_gpt":0.2569220737021098,"score_spread":0.2466987203569224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}