{"id":"W4323351104","doi":"10.1093/jcag/gwac036.033","title":"A33 EFFECTS OF THE NEXT GENERATION PROBIOTIC, AKKERMANSIA MUCINIPHILA, ON INTESTINAL INFLAMMATION AND BARRIER FUNCTION","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Akkermansia muciniphila; Akkermansia; Mucin; Barrier function; Colitis; Inflammation; Proinflammatory cytokine; Microbiology; Ulcerative colitis; Immune system; Immunology; Context (archaeology); Biology; Gut flora; Probiotic; Inflammatory bowel disease; Intestinal mucosa; Disease; Medicine; Bacteria; Lactobacillus; Pathology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537832,0.0004310809,0.000345969,0.0002343261,0.0001510654,0.0003042659,0.0001502397,0.0003946286,0.00160581],"category_scores_gemma":[0.0001547535,0.000113973,0.0003446291,0.0001376129,0.0001749888,0.0003593283,0.0002368818,0.0007552156,0.0002037519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001248519,"about_ca_system_score_gemma":0.0002027005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004301257,"about_ca_topic_score_gemma":0.0005089462,"domain_scores_codex":[0.9998713,0.00002861353,0.0000127683,0.00002055688,0.00002652408,0.00004024632],"domain_scores_gemma":[0.9998147,0.0000285848,0.00004391406,0.00001556224,0.00002201185,0.00007530618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002521477,0.0004076241,0.0004279427,0.0001210933,0.00001645773,0.00005600147,0.00001476421,0.00006115325,0.993068,0.00003246905,0.00004458895,0.003228494],"study_design_scores_gemma":[0.0001992173,0.02387953,0.02183401,0.00004136368,0.0001369843,0.0002754403,0.0001332636,0.001173915,0.9494737,0.0001011032,0.002733937,0.00001755909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961759,0.002556741,0.0003234336,0.00009614157,0.00006152421,0.0000201846,0.0001686144,0.00002857359,0.0005689896],"genre_scores_gemma":[0.9961035,0.001440277,0.0008152283,0.00007205237,0.00002782132,0.00002922646,0.0001999715,0.000005328003,0.001306644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00160581,"threshold_uncertainty_score":0.005371988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009770091589262408,"score_gpt":0.2122144689170239,"score_spread":0.2024443773277615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}