{"id":"W4323351148","doi":"10.1093/jcag/gwac036.175","title":"A175 REAL-WORLD EXPERIENCE ON SWITCHING FROM ADALIMUMAB TO BIOSIMILARS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE – AN OBSERVATIONAL STUDY FROM THREE TERTIARY CARE CENTRES","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Western University; Kelowna General Hospital; University of British Columbia","funders":"","keywords":"Biosimilar; Medicine; Adalimumab; Ulcerative colitis; Inflammatory bowel disease; Infliximab; Internal medicine; Crohn's disease; Faecal calprotectin; Calprotectin; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003871917,0.0001463669,0.0002987027,0.0003455926,0.0001300099,0.00001807474,0.000415684,0.000110438,0.00006898079],"category_scores_gemma":[0.0002609948,0.000104371,0.00009025582,0.0001940392,0.00004654377,0.0001077398,0.0000600462,0.0003471237,0.000003956901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007241812,"about_ca_system_score_gemma":0.0002231065,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.009702082,"about_ca_topic_score_gemma":0.7537191,"domain_scores_codex":[0.9980747,0.0006620809,0.0005262314,0.000205674,0.0001823625,0.0003490279],"domain_scores_gemma":[0.9986509,0.0001829559,0.0005441584,0.000235045,0.0002304175,0.0001564943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001198996,0.0001365125,0.9958291,0.000002150949,0.0001856094,0.00001178071,0.001165061,0.0001998848,0.0002343143,0.000006213041,0.0009003681,0.0001300021],"study_design_scores_gemma":[0.002233987,0.0006086492,0.996111,0.0000706612,0.00006996642,1.52343e-7,0.0005192062,0.00001396222,0.00005956886,0.00007767625,0.000165886,0.00006929339],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929215,0.000009017383,0.000004549232,0.005807132,0.0005688955,0.0002558458,0.0004203987,0.000006319265,0.000006399275],"genre_scores_gemma":[0.9975136,0.000002552439,0.00009369227,0.002245795,0.00004787063,0.000005734213,0.0000485462,0.00001177205,0.00003046746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.744017,"threshold_uncertainty_score":0.9968924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02286914280321149,"score_gpt":0.2722432630754599,"score_spread":0.2493741202722484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}