{"id":"W4323351148","doi":"10.1093/jcag/gwac036.175","title":"A175 REAL-WORLD EXPERIENCE ON SWITCHING FROM ADALIMUMAB TO BIOSIMILARS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE – AN OBSERVATIONAL STUDY FROM THREE TERTIARY CARE CENTRES","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Western University; Kelowna General Hospital; University of British Columbia","funders":"","keywords":"Biosimilar; Medicine; Adalimumab; Ulcerative colitis; Inflammatory bowel disease; Infliximab; Internal medicine; Crohn's disease; Faecal calprotectin; Calprotectin; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002621869,0.0002913801,0.00065072,0.001352299,0.001040661,0.001542683,0.0007348659,0.000790934,0.001705157],"category_scores_gemma":[0.00743922,0.0004252949,0.000636704,0.002328745,0.0009956254,0.0007807301,0.001204524,0.0008885674,0.0002563687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002102795,"about_ca_system_score_gemma":0.001753395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01136464,"about_ca_topic_score_gemma":0.01213315,"domain_scores_codex":[0.9955176,0.001673354,0.0007294813,0.0008343771,0.0007382456,0.0005069626],"domain_scores_gemma":[0.9848105,0.002942991,0.008568441,0.0006569311,0.001093156,0.001928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002903949,0.0002421906,0.9962889,0.00005189857,0.00007396244,0.0004283769,0.001174837,0.00004307346,0.0001694715,0.00001969821,0.0001067799,0.001110451],"study_design_scores_gemma":[0.00007061243,0.001206289,0.9928763,0.00004558103,0.00007863882,0.001117469,0.003778328,0.0001994286,0.0001572557,0.00001560032,0.0004306039,0.00002388488],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993693,0.0002088644,0.00004253118,0.00003459252,0.0000031961,0.00002464922,0.0001495551,0.000001332366,0.0001659459],"genre_scores_gemma":[0.9995185,0.00009106065,0.00005882604,0.00006884207,0.000009792688,0.00001759614,0.0001989946,0.00000144276,0.0000348584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01136464,"threshold_uncertainty_score":0.02259696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02286914280321149,"score_gpt":0.2722432630754599,"score_spread":0.2493741202722484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}