{"id":"W4323351206","doi":"10.1093/jcag/gwac036.023","title":"A23 INTESTINAL STEM CELL REGULATION BY THE BACTERIAL METABOLITE ADP-HEPTOSE VIA ACTIVATION OF THE ALPK1-TIFA SIGNALLING PATHWAY","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Hedgehog signaling pathway; Metabolite; Cell biology; Biology; Chemistry; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308778,0.0001920046,0.000181639,0.0003457168,0.0003342206,0.001039311,0.0001585846,0.0003031916,0.00964834],"category_scores_gemma":[0.0001677277,0.0001153073,0.0003945642,0.0002811358,0.0002056849,0.0003119864,0.0003694509,0.0006602278,0.002395435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005204312,"about_ca_system_score_gemma":0.0004624532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002450139,"about_ca_topic_score_gemma":0.003584902,"domain_scores_codex":[0.9998234,0.00001717079,0.00001103495,0.0000252525,0.00006198968,0.00006120084],"domain_scores_gemma":[0.9998803,0.00001458961,0.00002468861,0.00001149378,0.00002544446,0.00004354336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005652037,0.00004369647,0.001040956,0.0001061442,0.00001736323,0.0002828019,0.0000573427,0.0001375571,0.9880134,0.0009451612,0.001188957,0.007601373],"study_design_scores_gemma":[0.00007881334,0.0003259058,0.0474528,0.0000424101,0.00004674331,0.0005257905,0.0005452082,0.001489036,0.9152368,0.0005110445,0.03371993,0.00002571081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627115,0.005904683,0.00355286,0.001126911,0.0002463765,0.00005291048,0.004345554,0.0003946465,0.02166443],"genre_scores_gemma":[0.9825386,0.001441932,0.001335041,0.0001676156,0.00002037538,0.00004364448,0.001844158,0.00004806564,0.01256053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00964834,"threshold_uncertainty_score":0.03227693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008111495002553317,"score_gpt":0.2171312285589415,"score_spread":0.2090197335563882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}