{"id":"W4323351255","doi":"10.1093/jcag/gwac036.196","title":"A196 CROHN’S DISEASE PATIENT DERIVED MACROPHAGES ARE MORE SUSCEPTIBLE TO HYDROGEN PEROXIDE INDUCED CELL DEATH","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"GPX1; Selenoprotein; Calprotectin; Crohn's disease; Oxidative stress; Glutathione peroxidase; Immunology; Malondialdehyde; Medicine; Selenium deficiency; Internal medicine; Immune system; Endocrinology; Disease; Inflammatory bowel disease; Catalase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001318506,0.0002007085,0.0003270373,0.000556811,0.0002913264,0.0004430831,0.00009302664,0.0003718993,0.01020711],"category_scores_gemma":[0.0003009283,0.0001508331,0.0002032781,0.0002445712,0.0001595537,0.0001578704,0.0001870146,0.0003564286,0.001920333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001183391,"about_ca_system_score_gemma":0.00006164802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002175015,"about_ca_topic_score_gemma":0.0001383158,"domain_scores_codex":[0.9998528,0.00001877099,0.00002053501,0.00005414147,0.00002514433,0.00002860771],"domain_scores_gemma":[0.9997889,0.0000437792,0.00004559299,0.00002671355,0.00004892123,0.00004609415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004088424,0.0003550748,0.1026625,0.0002044035,0.00004386913,0.003657519,0.0003436388,0.0000717244,0.8765411,0.0001443623,0.0006731218,0.01121427],"study_design_scores_gemma":[0.0005836092,0.004881493,0.8048837,0.00008788623,0.0001719548,0.02662709,0.0015668,0.001048224,0.1425572,0.0007019723,0.01684369,0.00004646484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980626,0.0005044308,0.0002479161,0.00004891609,0.00002798653,0.00002021535,0.0003652756,0.00001664796,0.0007060034],"genre_scores_gemma":[0.996289,0.0002003663,0.000311116,0.0001193628,0.00003579054,0.00004075618,0.0007874926,0.000009314686,0.002206752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01020711,"threshold_uncertainty_score":0.03414619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007026200951496111,"score_gpt":0.2156072404411742,"score_spread":0.2085810394896781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}