{"id":"W4323351382","doi":"10.1093/jcag/gwac036.031","title":"A31 MIRIKIZUMAB IMPROVES QUALITY OF LIFE IN MODERATELY-TO-SEVERELY ACTIVE UC: IMPROVEMENT IN IBDQ SCORES IN PARTICIPANTS OF LUCENT-1 AND LUCENT-2 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 3 TRIALS","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Western University","funders":"","keywords":"Medicine; Minimal clinically important difference; Ulcerative colitis; Placebo; Inflammatory bowel disease; Randomization; Quality of life (healthcare); Clinical trial; Maintenance therapy; Crohn's disease; Internal medicine; Randomized controlled trial; Surgery; Physical therapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003720066,0.000968541,0.002401635,0.0003683559,0.0004833816,0.0008711873,0.0006453715,0.001267207,0.003871167],"category_scores_gemma":[0.002231126,0.0005350571,0.001947701,0.0003919613,0.0007386819,0.0006840915,0.0003643361,0.001478598,0.0004267004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004277051,"about_ca_system_score_gemma":0.0009268943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004002895,"about_ca_topic_score_gemma":0.001209942,"domain_scores_codex":[0.9981955,0.001217764,0.0001596489,0.0001807295,0.000115584,0.0001307814],"domain_scores_gemma":[0.9987599,0.0003556804,0.0003943885,0.00008023025,0.00009108965,0.0003188405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9608909,0.004458399,0.001834766,0.0007796547,0.001407138,0.00003632326,0.00004444756,0.0001428784,0.007282514,0.00005273775,0.0006457902,0.02242443],"study_design_scores_gemma":[0.8195398,0.1628237,0.01384159,0.00007204786,0.001285999,0.00006281058,0.00002356091,0.0003745789,0.0009649877,0.000111035,0.0008755728,0.00002437014],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823334,0.0111355,0.0006548991,0.0004480862,0.0002444077,0.003163948,0.0007363492,0.0001098088,0.001173451],"genre_scores_gemma":[0.9934639,0.001821507,0.001017847,0.0004022477,0.0001495723,0.002131828,0.0003984997,0.000007280986,0.0006072817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003871167,"threshold_uncertainty_score":0.01967376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03738215807400658,"score_gpt":0.3244058077015426,"score_spread":0.2870236496275361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}