{"id":"W4323352621","doi":"10.1016/j.cbi.2023.110447","title":"Modulation of cytochrome P450 1A (CYP1A) enzymes by monomethylmonothioarsonic acid (MMMTAV) in vivo and in vitro","year":2023,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"CYP1A2; Cytochrome P450; In vivo; Chemistry; Toxicity; In vitro; Enzyme; Toxicant; Messenger RNA; Inducer; Biochemistry; Biotransformation; Enzyme inducer; CYP2E1; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002072536,0.0003329904,0.0002093024,0.000166979,0.0002031508,0.0002470105,0.0001496673,0.0003184143,0.001695852],"category_scores_gemma":[0.000205741,0.0001785709,0.000345012,0.0001546505,0.0002035872,0.000139721,0.000109149,0.0004244015,0.0002728098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002669801,"about_ca_system_score_gemma":0.0002128397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001620068,"about_ca_topic_score_gemma":0.002698531,"domain_scores_codex":[0.9998214,0.00007807763,0.00001055474,0.00003025535,0.0000196042,0.00004014817],"domain_scores_gemma":[0.9998767,0.00003844932,0.00003058673,0.00001708947,0.00001521313,0.00002178908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001042026,0.00009024526,0.0006686526,0.00004890213,0.00003352268,0.00005739905,0.00002568259,0.0001499301,0.9947546,0.00009881734,0.0001077979,0.002922455],"study_design_scores_gemma":[0.00002916257,0.001187539,0.003040157,0.00000300887,0.0000289679,0.0001159253,0.00002538399,0.0004855704,0.9939307,0.00003857315,0.001111191,0.000003930872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936427,0.002333401,0.002188203,0.0001555308,0.00006069179,0.00002149579,0.0001869539,0.00008327823,0.001327706],"genre_scores_gemma":[0.9974006,0.0006103659,0.0005869272,0.00003123259,0.00001403431,0.00001114373,0.0001683853,0.000007333355,0.001169883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695852,"threshold_uncertainty_score":0.00567317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210059432062276,"score_gpt":0.2670658211240463,"score_spread":0.2460598779178187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}