{"id":"W4323352621","doi":"10.1016/j.cbi.2023.110447","title":"Modulation of cytochrome P450 1A (CYP1A) enzymes by monomethylmonothioarsonic acid (MMMTAV) in vivo and in vitro","year":2023,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"CYP1A2; Cytochrome P450; In vivo; Chemistry; Toxicity; In vitro; Enzyme; Toxicant; Messenger RNA; Inducer; Biochemistry; Biotransformation; Enzyme inducer; CYP2E1; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001520644,0.00009611679,0.0001485652,0.00008977398,0.00003775356,0.000009133486,0.00008544444,0.00008908976,0.0008772779],"category_scores_gemma":[0.00009627898,0.00008858563,0.00003630615,0.0003691023,0.0001266226,0.0002045073,0.00008014607,0.0001539394,0.00005328012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718958,"about_ca_system_score_gemma":0.000004893215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062174,"about_ca_topic_score_gemma":0.0001136666,"domain_scores_codex":[0.9991891,0.00004114764,0.0002749932,0.0002586149,0.0000753038,0.0001608002],"domain_scores_gemma":[0.9996142,0.0001495975,0.00008557214,0.0001012992,0.0000061486,0.00004312584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002510393,0.0000572955,0.005089589,0.000002598493,0.000002508697,0.000001126161,0.0003233715,0.00007079676,0.9907395,0.00003245816,0.0004142338,0.003241377],"study_design_scores_gemma":[0.0003603921,0.00003339078,0.1804672,0.00001633611,0.000002787448,0.000004040829,0.0004897202,0.008577044,0.8070297,0.0004301955,0.002452472,0.0001366224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971082,0.00003064432,0.0001444333,0.0003243715,0.00003723844,0.0001603135,0.00002350297,0.00003816697,0.002133122],"genre_scores_gemma":[0.9989823,0.00008393105,0.0001640089,0.00006373404,0.000009434654,0.00004910757,0.00006196598,0.000005184565,0.0005803644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1837098,"threshold_uncertainty_score":0.9605578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210059432062276,"score_gpt":0.2670658211240463,"score_spread":0.2460598779178187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}