{"id":"W4323353115","doi":"10.1093/jcag/gwac036.060","title":"A60 DOWN WITH THE SHP-1: CHRONIC HELMINTH INFECTION DISRUPTS BILE ACID HOMEOSTASIS AND SIGNALLING RECEPTOR ACTIVATION IN THE MURINE SMALL INTESTINE TO POTENTIALLY IMPACT GUT IMMUNITY","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Small intestine; Biology; Farnesoid X receptor; Heligmosomoides polygyrus; Homeostasis; Immunology; Receptor; Immune system; Helminths; Immunity; Cell biology; Transcription factor; Endocrinology; Nuclear receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003591,0.0005008032,0.0004860221,0.0005362802,0.0002301367,0.0004424059,0.0002572734,0.0006026634,0.003944058],"category_scores_gemma":[0.0001279722,0.0002900934,0.0005470953,0.0003185712,0.000523548,0.0003579248,0.0002737934,0.001391499,0.001124359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003050173,"about_ca_system_score_gemma":0.0003295232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006242028,"about_ca_topic_score_gemma":0.0009921881,"domain_scores_codex":[0.9995787,0.00004441461,0.00005019145,0.00009737451,0.0001019737,0.0001273977],"domain_scores_gemma":[0.999705,0.0000355001,0.00009819867,0.00003386607,0.00002458598,0.0001028122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002809082,0.00006190185,0.0001330829,0.00003188903,0.000004899416,0.0000285162,0.00001313161,0.00002747494,0.9987192,0.0000405994,0.00005628675,0.0006021915],"study_design_scores_gemma":[0.00008612383,0.001735741,0.008192922,0.00001881278,0.00004024719,0.0001894084,0.000127703,0.0008333341,0.9853415,0.00009805708,0.003327023,0.00000910684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922512,0.001375474,0.00269191,0.0004054487,0.0001312674,0.00005974137,0.001474551,0.0001638587,0.001446558],"genre_scores_gemma":[0.9827545,0.001505156,0.002790417,0.0003290398,0.00003407959,0.0001737546,0.001411314,0.00007858293,0.0109232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003944058,"threshold_uncertainty_score":0.0131942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009615477900849686,"score_gpt":0.2344086492405681,"score_spread":0.2247931713397184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}