{"id":"W4323353235","doi":"10.1093/jcag/gwac036.061","title":"A61 TARGETING A GUANINE QUADRUPLEX IN THE HEPATITIS B VIRUS COVALENTLY CLOSED CIRCULAR DNA GENOME USING SINGLE DOMAIN ANTIBODIES","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Lethbridge; University of Calgary","funders":"","keywords":"cccDNA; HBx; Hepatitis B virus; Virology; Microscale thermophoresis; Molecular biology; DNA; Oligonucleotide; Biology; Recombinant DNA; Virus; Chemistry; HBsAg; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002128727,0.0004598263,0.0001978725,0.0002518578,0.0001181261,0.0003121991,0.0002395591,0.000502346,0.001203236],"category_scores_gemma":[0.0001850342,0.0001862487,0.0002879065,0.0001180098,0.0001704091,0.0001612631,0.0001940059,0.0005216455,0.0006153994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004646642,"about_ca_system_score_gemma":0.0001644264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005239639,"about_ca_topic_score_gemma":0.0007817478,"domain_scores_codex":[0.9997589,0.00004149419,0.00002082634,0.00004648326,0.00006926863,0.00006301143],"domain_scores_gemma":[0.9998281,0.00004059912,0.00004180821,0.00001953084,0.00003602488,0.00003396025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002106748,0.00003040588,0.00007675872,0.00001209395,0.00000321954,0.000009431868,0.000003371919,0.00004788391,0.9992074,0.00003749322,0.00001725921,0.0005335574],"study_design_scores_gemma":[0.00001107094,0.0003800985,0.0009457775,0.000004326068,0.00001083045,0.00009088772,0.000006581034,0.001610847,0.9958579,0.00002424987,0.001054665,0.000002834295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890857,0.0006194768,0.008300745,0.00008563537,0.00002997436,0.00006362527,0.0001246352,0.000112084,0.001578185],"genre_scores_gemma":[0.9866398,0.000401428,0.008584836,0.0001255408,0.0000102276,0.00005904262,0.0004747342,0.00001887861,0.00368549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203236,"threshold_uncertainty_score":0.004025221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303659175958966,"score_gpt":0.227064619286328,"score_spread":0.2140280275267383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}