{"id":"W4323353317","doi":"10.1093/jcag/gwac036.010","title":"A10 OVEREXPRESSION OF ASCL2 ALTERS DIFFERENTIATION, CELL CYCLE AND RESISTANCE TO ANTI-CANCER TREATMENT IN ESOPHAGEAL ORGANOIDS","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Organoid; Stem cell; Cell biology; Wnt signaling pathway; Biology; Cellular differentiation; Stem cell marker; Immunostaining; Cancer stem cell; Adult stem cell; Cancer research; Immunology; Signal transduction; Immunohistochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001164767,0.0002351701,0.0002273092,0.0002675693,0.0001368337,0.0002577475,0.0001562141,0.000278323,0.001506095],"category_scores_gemma":[0.00007038785,0.0001033541,0.0003183997,0.0001899986,0.0001497544,0.0001723059,0.0001283532,0.0005374708,0.0005289181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000246676,"about_ca_system_score_gemma":0.0001454541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00087939,"about_ca_topic_score_gemma":0.0007285005,"domain_scores_codex":[0.9998903,0.00001353551,0.00001779011,0.00002355784,0.00002957694,0.00002524663],"domain_scores_gemma":[0.9998823,0.00001766276,0.00002138862,0.00002043481,0.00001442146,0.00004383159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001637669,0.00005575466,0.0002791652,0.00002379076,0.000004739114,0.00006287514,0.00001855275,0.00007082514,0.9983281,0.00004171425,0.0001262479,0.00082452],"study_design_scores_gemma":[0.00001562082,0.0005698739,0.004455351,0.000004261666,0.00001456787,0.0001643411,0.00005377224,0.0009904425,0.9915125,0.00002207591,0.002192938,0.000004354789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946596,0.0009897404,0.001320616,0.0001203428,0.00005985069,0.00002601558,0.00103484,0.0001275781,0.001661412],"genre_scores_gemma":[0.9919293,0.0004398621,0.001021674,0.0000603731,0.000006930261,0.00005058206,0.001120793,0.00001830649,0.005352113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001506095,"threshold_uncertainty_score":0.005038381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00815612315335532,"score_gpt":0.245620752309322,"score_spread":0.2374646291559667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}