{"id":"W4323353470","doi":"10.21203/rs.3.rs-2587403/v1","title":"Signatures of Original Antigenic Sin or protection following coronavirus imprinting in Syrian hamsters challenged with SARS-CoV-2 or variants","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Centre for Disease Control; Queen's University; University of British Columbia; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Coalition for Epidemic Preparedness Innovations; Innovation Saskatchewan","keywords":"Virology; Coronavirus; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Syrian hamsters; Imprinting (psychology); Biology; 2019-20 coronavirus outbreak; Antigen; Genetics; Medicine; Molecular biology; Gene; Hamster; Infectious disease (medical specialty); Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009387158,0.000132276,0.0002222165,0.0001882871,0.00009387597,0.0002978568,0.0001038872,0.000204782,0.001441153],"category_scores_gemma":[0.0001316973,0.0001146853,0.000183398,0.0001146637,0.0002156934,0.0001662701,0.0002027566,0.0003275181,0.0002544495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001445799,"about_ca_system_score_gemma":0.0001046559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006227687,"about_ca_topic_score_gemma":0.0005429271,"domain_scores_codex":[0.9999322,0.000005797146,0.000003585736,0.0000184685,0.000009070956,0.00003091002],"domain_scores_gemma":[0.9998789,0.00002120375,0.00003104622,0.00002134654,0.00001458573,0.00003297118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001041407,0.00002976862,0.005146206,0.00001852343,0.00001139243,0.00007772355,0.00005199376,0.00003941773,0.9925101,0.00008899329,0.00003259478,0.0009519829],"study_design_scores_gemma":[0.00003096715,0.001658833,0.5985281,0.000009079103,0.00005664275,0.0004132219,0.0003609605,0.0009580477,0.396726,0.0002402412,0.00100046,0.00001748193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991364,0.0001333346,0.00009075488,0.0000114915,0.00001139664,0.000001993692,0.0001668108,0.000007000014,0.0004409783],"genre_scores_gemma":[0.9986333,0.00008674463,0.00006534397,0.00001851289,0.000004843046,0.000003655019,0.0002884613,0.000005119278,0.0008939243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001441153,"threshold_uncertainty_score":0.004821122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2356476992088408,"score_gpt":0.4654983662602747,"score_spread":0.229850667051434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}