{"id":"W4323353562","doi":"10.1093/brain/awad072","title":"Progression of clinical markers in prodromal Parkinson’s disease and dementia with Lewy bodies: a multicentre study","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Hôpital du Sacré-Cœur de Montréal; Université du Québec à Montréal; Canadian Sleep & Circadian Network; Montreal Neurological Institute and Hospital","funders":"National Research Foundation of Korea; Edmond J. Safra Center for Ethics, Harvard University; Ministry of Science, ICT and Future Planning; National Research Foundation; ParkinsonFonds Deutschland; Parkinson's UK; Canadian Institutes of Health Research; National Institute for Health and Care Research; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dementia with Lewy bodies; REM sleep behavior disorder; Dementia; Prodromal Stage; Cognitive decline; Parkinson's disease; Psychology; Lewy body; Subclinical infection; Disease; Internal medicine; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009659213,0.001382037,0.00161899,0.00134447,0.0009510747,0.001092799,0.00124525,0.001478712,0.0006985012],"category_scores_gemma":[0.01136354,0.0009603794,0.001855217,0.001591859,0.0007773949,0.001075995,0.001315098,0.0008862566,0.0003128949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008390281,"about_ca_system_score_gemma":0.0008625877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005266265,"about_ca_topic_score_gemma":0.004647668,"domain_scores_codex":[0.9931491,0.004105574,0.0005576852,0.001146026,0.0006559005,0.0003857977],"domain_scores_gemma":[0.9915884,0.001827577,0.002164937,0.002295629,0.0008886569,0.001234744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03082489,0.001565727,0.956856,0.0001361747,0.001610226,0.0005019896,0.001060806,0.0005676543,0.001326281,0.00005341839,0.0002284106,0.005268449],"study_design_scores_gemma":[0.001743231,0.006376797,0.9897558,0.00001591957,0.0004708724,0.0003628903,0.0001443642,0.000660817,0.0001429097,0.00003217222,0.0002585227,0.00003560868],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990276,0.0003052002,0.0001774523,0.00001136496,0.00000734826,0.0001587809,0.0001809799,0.000005048733,0.00012616],"genre_scores_gemma":[0.9987403,0.00007970088,0.0003277717,0.00002338137,0.0000175294,0.0001487012,0.000552975,0.000004024876,0.0001056602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009659213,"threshold_uncertainty_score":0.05108345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03300589820808495,"score_gpt":0.3562287506633132,"score_spread":0.3232228524552282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}