{"id":"W4323353562","doi":"10.1093/brain/awad072","title":"Progression of clinical markers in prodromal Parkinson’s disease and dementia with Lewy bodies: a multicentre study","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Hôpital du Sacré-Cœur de Montréal; Université du Québec à Montréal; Canadian Sleep & Circadian Network; Montreal Neurological Institute and Hospital","funders":"National Research Foundation of Korea; Edmond J. Safra Center for Ethics, Harvard University; Ministry of Science, ICT and Future Planning; National Research Foundation; ParkinsonFonds Deutschland; Parkinson's UK; Canadian Institutes of Health Research; National Institute for Health and Care Research; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dementia with Lewy bodies; REM sleep behavior disorder; Dementia; Prodromal Stage; Cognitive decline; Parkinson's disease; Psychology; Lewy body; Subclinical infection; Disease; Internal medicine; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000474936,0.0001463487,0.0003335582,0.0001238327,0.00003966481,0.000009881514,0.00004598088,0.00003890559,0.00002835699],"category_scores_gemma":[0.0002388431,0.0001021572,0.00005399529,0.0001866291,0.00006199502,0.00005170731,0.00006801804,0.00008605472,0.00001003734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001752435,"about_ca_system_score_gemma":0.000123376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003742272,"about_ca_topic_score_gemma":0.0001267954,"domain_scores_codex":[0.9985678,0.0001450863,0.0003358605,0.0004002148,0.0003143105,0.0002367624],"domain_scores_gemma":[0.9992445,0.0001066604,0.0001064414,0.0002285443,0.00003086337,0.0002829686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003817414,0.002390775,0.9710671,0.0001416866,0.0003128957,0.00142766,0.0004629136,0.000001131958,0.00003304016,0.000006380821,0.0004187548,0.01992029],"study_design_scores_gemma":[0.01035191,0.001264589,0.9839486,0.0003437019,0.0003454977,0.000002924313,0.001140006,0.0007857085,0.00002022006,0.00002274823,0.001678033,0.00009602587],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972806,0.0002938751,0.000003958955,0.0005021549,0.00004494376,0.00170346,0.00002133748,0.00005626186,0.00009341404],"genre_scores_gemma":[0.9989122,0.00004617679,0.0005401507,0.00007856251,0.0000280475,0.0001619589,0.00003254847,0.00002059156,0.0001798134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01982427,"threshold_uncertainty_score":0.416585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03300589820808495,"score_gpt":0.3562287506633132,"score_spread":0.3232228524552282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}