{"id":"W4323354020","doi":"10.4049/jimmunol.2200646","title":"cIAP1/2 Antagonism Induces Antigen-Specific T Cell–Dependent Immunity","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Moonshot; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; Moderna; National Institute of Diabetes and Digestive and Kidney Diseases; Novartis Institutes for BioMedical Research; Tillotts Pharma; Moonshot Research and Development Program; Bristol-Myers Squibb; Eli Lilly and Company; Foghorn Therapeutics; Society for Immunotherapy of Cancer; Mallinckrodt Pharmaceuticals; Novartis; National Cancer Institute; Melanoma Research Alliance; Ludwig Center at Harvard; Deutsche Forschungsgemeinschaft","keywords":"Biology; Cancer research; Cytotoxic T cell; T cell; CD28; Cell biology; Immune system; Immunology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145399,0.000918313,0.0005368998,0.0004587459,0.0001873535,0.0004128758,0.0002874989,0.0004245805,0.001440329],"category_scores_gemma":[0.0001309313,0.0002260045,0.000380587,0.0002409131,0.0002987589,0.0003107491,0.0002350919,0.002108827,0.0004385446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003379689,"about_ca_system_score_gemma":0.0003675216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002384526,"about_ca_topic_score_gemma":0.0004559778,"domain_scores_codex":[0.9996372,0.0000550141,0.00003441513,0.00006889702,0.00008169543,0.0001227026],"domain_scores_gemma":[0.9998078,0.00002831146,0.00005515357,0.00003016902,0.0000122422,0.00006630773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004568695,0.0003136244,0.0001233075,0.00008068656,0.00001432853,0.00006317296,0.0000152957,0.0002174905,0.9959872,0.0001466271,0.0001437321,0.002437553],"study_design_scores_gemma":[0.0001688034,0.002751773,0.001784635,0.00001096003,0.00003588231,0.0003757256,0.00002148786,0.001490612,0.9902703,0.00008133343,0.003001082,0.000007401669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993225,0.001347392,0.001672857,0.000144242,0.0001042039,0.00009617296,0.0003707294,0.0001899283,0.002849431],"genre_scores_gemma":[0.9938969,0.0008851158,0.001324842,0.0001390494,0.00005165802,0.0001247198,0.0005516679,0.00002949728,0.002996545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440329,"threshold_uncertainty_score":0.00481832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0315629959148587,"score_gpt":0.2834355051629644,"score_spread":0.2518725092481057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}