{"id":"W4323361275","doi":"10.1101/2023.03.03.530083","title":"Electron microscopic analysis of the influence of iPSC-derived motor neurons on bioengineered human skeletal muscle tissues","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canada First Research Excellence Fund; Ontario Institute for Regenerative Medicine; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Sarcomere; Duchenne muscular dystrophy; Skeletal muscle; Neuroscience; Myocyte; Cell biology; Biology; Induced pluripotent stem cell; Muscular dystrophy; Anatomy; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002534426,0.0002019736,0.0001291705,0.0002885982,0.0001844125,0.0001928686,0.000136841,0.0003788793,0.001471628],"category_scores_gemma":[0.0001100713,0.0001376541,0.0001623928,0.0002035981,0.0002276047,0.0001299034,0.0001753942,0.0003095014,0.0004357728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978866,"about_ca_system_score_gemma":0.0001052735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009697469,"about_ca_topic_score_gemma":0.001246541,"domain_scores_codex":[0.9999044,0.00001295391,0.00001205011,0.00001854848,0.0000349689,0.00001709551],"domain_scores_gemma":[0.9998145,0.00007139982,0.00002189278,0.00003447277,0.0000389091,0.00001889853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003083265,0.0000160378,0.0002979523,0.00003739386,0.000007253272,0.0001811147,0.00004516655,0.0001798991,0.9978689,0.0001420556,0.00004301237,0.001150395],"study_design_scores_gemma":[0.00001146312,0.0001241693,0.02214822,0.00002922828,0.00003279452,0.0007575423,0.000121452,0.002400739,0.9704428,0.0001144849,0.003808564,0.000008600027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709145,0.002145193,0.01677017,0.0001038801,0.00009478904,0.00004983341,0.001202327,0.0001855186,0.00853381],"genre_scores_gemma":[0.9720781,0.001440222,0.01705534,0.00009626531,0.00001662921,0.00007999511,0.001380835,0.000115142,0.007737496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001471628,"threshold_uncertainty_score":0.004923105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009390661761002677,"score_gpt":0.2372241044136196,"score_spread":0.227833442652617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}