{"id":"W4323364828","doi":"10.3390/ijms24065065","title":"Distinct Plasma Immune Profile in ALS Implicates sTNFR-II in pAMPK/Leptin Homeostasis","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université Laval","funders":"ALS Society of Canada","keywords":"Leptin; Immune system; AMPK; Biology; Internal medicine; Endocrinology; Homeostasis; Immunology; Protein kinase A; Medicine; Phosphorylation; Cell biology; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232583,0.0003299947,0.000267349,0.0003785415,0.0001512953,0.0002417414,0.00007196779,0.000234727,0.0009815589],"category_scores_gemma":[0.00008801843,0.00009407097,0.0001916996,0.0002027508,0.0001826806,0.0001275746,0.0001603122,0.0003390677,0.0001998431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001083139,"about_ca_system_score_gemma":0.00007691641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001457723,"about_ca_topic_score_gemma":0.0002589769,"domain_scores_codex":[0.9998986,0.00001759833,0.00001438228,0.00002708482,0.00002579416,0.00001662709],"domain_scores_gemma":[0.9999415,0.000006613663,0.00002509151,0.000004057208,0.000007491024,0.00001528612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005944405,0.0000291623,0.01221797,0.00006662673,0.00001929162,0.0003677671,0.00006109489,0.00003641028,0.983512,0.00003498298,0.00003415113,0.003026116],"study_design_scores_gemma":[0.00007821965,0.002859052,0.6202745,0.00004388524,0.0001278661,0.007768614,0.0003989344,0.0009260452,0.363783,0.000363836,0.003357346,0.00001868582],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973354,0.001154297,0.0007474651,0.00003296782,0.000008756347,0.0000148452,0.0002510128,0.00002173778,0.0004334671],"genre_scores_gemma":[0.9978247,0.0004573905,0.0007458974,0.00005569695,0.00001118841,0.00002402093,0.0003735538,0.000005410803,0.0005021812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009815589,"threshold_uncertainty_score":0.003283679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03717677815288985,"score_gpt":0.359735553323394,"score_spread":0.3225587751705041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}