{"id":"W4323528402","doi":"10.2139/ssrn.4380032","title":"A Multi-Centre Randomised Phase II Trial of Early Pet-Ct Directed Switch to Carboplatin and Paclitaxel Based Definitive Chemoradiotherapy in Patients with Oesophageal Cancer Who Have a Poor Early Response to Induction Cisplatin and Capecitabine","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre","funders":"","keywords":"Carboplatin; Paclitaxel; Medicine; Chemoradiotherapy; Cancer; Oncology; Radiology; Internal medicine; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001807187,0.00206628,0.003022584,0.0003672405,0.0004747135,0.001691338,0.001006368,0.002139585,0.007944594],"category_scores_gemma":[0.00191776,0.0008468566,0.002656389,0.0004668443,0.001541092,0.001208397,0.0007015029,0.005036353,0.001169199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001283533,"about_ca_system_score_gemma":0.001730361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002099171,"about_ca_topic_score_gemma":0.004613532,"domain_scores_codex":[0.9992151,0.0003607981,0.00003653538,0.0001919132,0.00003489577,0.000160629],"domain_scores_gemma":[0.9987803,0.0003152922,0.0001866919,0.0001419343,0.00005484306,0.0005208274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9861583,0.006360633,0.0004462792,0.00008220461,0.0003798374,0.00002093729,0.00003056759,0.0003157807,0.001334461,0.00004012286,0.0003596794,0.004471312],"study_design_scores_gemma":[0.945953,0.05132216,0.001783138,0.000008840096,0.0002149269,0.00001734109,0.00001574502,0.0001979274,0.0001667724,0.00007979978,0.0002302071,0.00001008377],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929886,0.00089895,0.0004573034,0.0007500014,0.0005615558,0.002152239,0.0008411605,0.00006344196,0.001286739],"genre_scores_gemma":[0.9872552,0.0009383418,0.001627129,0.001737739,0.0004376552,0.002976509,0.001906718,0.00004022771,0.003080459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007944594,"threshold_uncertainty_score":0.02657729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590727500211852,"score_gpt":0.28678093072308,"score_spread":0.2708736557209615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}