{"id":"W4323530529","doi":"10.1016/j.cmet.2023.02.004","title":"Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1","year":2023,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; H2020 Marie Skłodowska-Curie Actions; H2020 European Research Council; European Research Council; Horizon 2020; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Horizon 2020 Framework Programme; Novo Nordisk; Helmholtz Association; European Commission","keywords":"Leptin; Melanocortin; Biology; Endocrinology; Internal medicine; Hormone; Hypothalamus; Crosstalk; Adipose tissue; STAT3; Adipokine; Leptin receptor; Proopiomelanocortin; Endocrine system; Signal transduction; Obesity; Cell biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007032599,0.0001952112,0.0001217201,0.0002225521,0.0001444063,0.0003041006,0.000233531,0.000163496,0.00142202],"category_scores_gemma":[0.0001206454,0.0001052604,0.0001468681,0.00009459567,0.0001888299,0.0001528103,0.0002007422,0.0003663359,0.0002937347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003229188,"about_ca_system_score_gemma":0.0001706787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006202175,"about_ca_topic_score_gemma":0.001440458,"domain_scores_codex":[0.999933,0.000006251595,0.00000376736,0.00001731139,0.00001731832,0.0000223763],"domain_scores_gemma":[0.9999317,0.000007732559,0.0000242533,0.000005151525,0.000009932287,0.00002135354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002089183,0.00002406988,0.001179863,0.00003435431,0.000006816891,0.0001314367,0.00002471236,0.00006609933,0.9941604,0.0004260848,0.00009785996,0.003639328],"study_design_scores_gemma":[0.0000768375,0.0002988226,0.07932323,0.00002974023,0.0000489522,0.0009612052,0.0001591498,0.002026206,0.9039351,0.0005733717,0.01254746,0.00001996851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883049,0.004060321,0.002460852,0.0002595065,0.00005216743,0.00001370518,0.0003546026,0.00007351436,0.00442051],"genre_scores_gemma":[0.9931685,0.001757029,0.001047404,0.00008332498,0.00001524768,0.00001369968,0.0002665474,0.00002175302,0.003626494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142202,"threshold_uncertainty_score":0.004757106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01971523934716653,"score_gpt":0.2353865977971686,"score_spread":0.215671358450002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}