{"id":"W4323531778","doi":"10.1073/pnas.2208695120","title":"Diverse yeast antiviral systems prevent lethal pathogenesis caused by the L-A mycovirus","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Plant and Fungal Interactions Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biology; Saccharomyces cerevisiae; Viral replication; Virology; Yeast; Genetics; Computational biology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008265734,0.00005452336,0.00006240799,0.00005945323,0.0001908007,0.00002494901,0.0005233571,0.00005636677,0.000003185538],"category_scores_gemma":[0.0002065101,0.00003088585,0.00005562278,0.0003760205,0.0003269101,0.00001663644,0.0001799644,0.00007968774,0.000005890971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008722487,"about_ca_system_score_gemma":0.00002389567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001529271,"about_ca_topic_score_gemma":1.822236e-7,"domain_scores_codex":[0.9990024,0.00001246259,0.0001346687,0.000151596,0.0005767272,0.0001221226],"domain_scores_gemma":[0.999693,0.00003401973,0.0001210239,0.000008482539,0.0001264253,0.00001701855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001116162,0.00001743918,0.002568378,0.00001468768,0.00001613568,1.008662e-8,0.00002642774,0.00004108236,0.981342,0.0005038183,0.01531759,0.000141262],"study_design_scores_gemma":[0.00009442866,0.00005015856,0.02403562,0.00002944926,0.000008050321,0.000008705954,0.0005077433,0.00102535,0.9696085,0.0001909777,0.004376273,0.00006475145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969994,0.0001316166,5.588217e-7,0.0006449605,0.0000343643,0.0001269522,0.0001462607,0.000004280186,0.001911606],"genre_scores_gemma":[0.9980854,0.00008554124,0.000008915894,0.00003729535,0.00009488205,0.00001365692,0.000002203418,0.000002426913,0.001669681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02146724,"threshold_uncertainty_score":0.1467504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05434859500944505,"score_gpt":0.3330725930692093,"score_spread":0.2787239980597642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}