{"id":"W4323533060","doi":"10.1091/mbc.e22-05-0157","title":"The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges","year":2023,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Université Laval","keywords":"Biology; Gene isoform; Genome instability; Fragile X syndrome; Genetics; RNA-binding protein; FMR1; Alternative splicing; DNA repair; RNA splicing; RNA; DNA; Cell biology; Gene; Protein isoform; DNA damage; Fragile x","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000897678,0.0002453933,0.0001065693,0.0002317372,0.0001241756,0.0001815841,0.0001372398,0.0001753124,0.0005131718],"category_scores_gemma":[0.0001130623,0.00009422655,0.0001311285,0.0001165883,0.000184991,0.0001964455,0.0002194444,0.0002042355,0.0002236478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000137034,"about_ca_system_score_gemma":0.00008897227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001840659,"about_ca_topic_score_gemma":0.000464456,"domain_scores_codex":[0.9999348,0.000008250113,0.00000426364,0.00002369716,0.00001934314,0.000009618372],"domain_scores_gemma":[0.9998885,0.00001348983,0.00005393705,0.00001697659,0.00001087206,0.0000161848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001716881,0.000003030839,0.0008015145,0.00001268331,0.000004463338,0.0001120307,0.00001385567,0.00001659255,0.9971649,0.0001342101,0.00001571893,0.001703758],"study_design_scores_gemma":[0.00001255303,0.000183692,0.06421806,0.00001459738,0.00003240243,0.004244032,0.0001104045,0.0007270553,0.9232627,0.000438809,0.006745059,0.00001062965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911461,0.002540836,0.005161793,0.00006459975,0.00001107414,0.000007574934,0.0001075678,0.00005098451,0.0009094274],"genre_scores_gemma":[0.9950514,0.0007831122,0.002331099,0.00002669428,0.00000805895,0.000009956136,0.0002519241,0.00001253097,0.001525059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005131718,"threshold_uncertainty_score":0.001716733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004569542229425743,"score_gpt":0.1959490561869709,"score_spread":0.1913795139575452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}