{"id":"W4323533212","doi":"10.1089/scd.2022.0300","title":"Opening the “Black Box” Underlying Barriers to the Use of Canine Induced Pluripotent Stem Cells: A Narrative Review","year":2023,"lang":"en","type":"review","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University; University of Guelph","funders":"","keywords":"Reprogramming; Induced pluripotent stem cell; Biology; Regenerative medicine; Somatic cell; Epigenetics; Stem cell; Drug discovery; Narrative review; Biotechnology; Disease; Computational biology; Bioinformatics; Neuroscience; Embryonic stem cell; Cell biology; Genetics; Cell; Gene; Pathology; Medicine; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001314878,0.0006651322,0.001336821,0.0001218752,0.0004804228,0.0001456566,0.00090314,0.000285579,0.00002543303],"category_scores_gemma":[0.00004188161,0.0003763265,0.0002874912,0.00054788,0.0001289414,0.000009468326,0.001338221,0.0004513552,0.00008520408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001434962,"about_ca_system_score_gemma":0.001756385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006598445,"about_ca_topic_score_gemma":0.0001278025,"domain_scores_codex":[0.9958411,0.00068895,0.001196614,0.0009391575,0.0006721979,0.0006619676],"domain_scores_gemma":[0.9977399,0.0001862478,0.0005481155,0.0008989631,0.0002235244,0.0004033133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007019369,0.00006275855,0.000006482366,0.07734881,0.002545041,0.00008801482,0.005027637,0.0002970874,0.005211872,0.00001368694,0.0500306,0.8592978],"study_design_scores_gemma":[0.000155728,0.0001188092,0.000001339691,0.01673679,0.0001723843,0.00001956884,0.001535839,0.000008299845,0.004244705,3.030881e-7,0.9765269,0.0004793835],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001327251,0.9933372,0.0001212468,0.0002429218,0.0003533828,0.004416217,0.00009174123,0.00001765862,0.00009243123],"genre_scores_gemma":[0.0002259002,0.9932277,0.0002572211,0.0003589048,0.00006517862,0.0004730587,0.00007114751,0.0001040763,0.005216865],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9264963,"threshold_uncertainty_score":0.9998689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.170264614208861,"score_gpt":0.3503463408181915,"score_spread":0.1800817266093305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}