{"id":"W4323535427","doi":"10.1002/anie.202218698","title":"The Self‐Association of the KRAS4b Protein is Altered by Lipid‐Bilayer Composition and Electrostatics","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Gyeonggi-do Regional Research Center; CHA University; National Research Foundation; National Research Foundation of Korea; Canada Foundation for Innovation; Princess Margaret Cancer Foundation","keywords":"KRAS; Dimer; Lipid bilayer; Biophysics; Chemistry; Electrostatics; Effector; Membrane; Phosphatidylcholine; Bilayer; Phosphatidylserine; Static electricity; Cell biology; Crystallography; Biochemistry; Biology; Mutation; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009879154,0.0001355717,0.00009177309,0.0001128554,0.0001613449,0.0002259944,0.0001457775,0.0001504758,0.001038578],"category_scores_gemma":[0.0001602988,0.0001252964,0.0001108035,0.0001220665,0.0001636607,0.0001765764,0.0001915049,0.0002677568,0.0002564657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379869,"about_ca_system_score_gemma":0.0001303203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006467609,"about_ca_topic_score_gemma":0.0005447411,"domain_scores_codex":[0.9999135,0.00001338018,0.000005426776,0.00001942881,0.00003067782,0.00001762131],"domain_scores_gemma":[0.9999528,0.000009525772,0.00001478486,0.000003719631,0.000008054604,0.00001102163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004341828,0.000008932329,0.0001658965,0.00001103317,0.000003501558,0.00001502533,0.00001297003,0.00004152475,0.9990498,0.00007403103,0.0000200764,0.0005537302],"study_design_scores_gemma":[0.000006878176,0.00004508119,0.003012701,0.000002783931,0.000005449467,0.00009205575,0.00003838527,0.001694632,0.994437,0.00006251757,0.0005970309,0.000005533208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978439,0.0002063628,0.001084604,0.00004366475,0.000007753296,0.000004625062,0.00008003163,0.00002091,0.000708135],"genre_scores_gemma":[0.9985532,0.0001441266,0.0005908757,0.00002222322,0.000001496663,0.000005671021,0.00008563661,0.000007043096,0.0005896589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038578,"threshold_uncertainty_score":0.003474414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00513497185182266,"score_gpt":0.2385201571008209,"score_spread":0.2333851852489982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}