{"id":"W4323536767","doi":"10.1101/2023.03.07.531617","title":"Functional analysis of flavivirus replicase by deep mutational scanning of dengue NS5","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Grand Challenges Canada; National Science and Technology Development Agency","keywords":"Dengue virus; Biology; RNA-dependent RNA polymerase; Flavivirus; Viral replication; Dengue fever; Virology; Antiviral drug; Zika virus; RNA; Virus; Interferon; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002592717,0.0003397002,0.0002660953,0.0003152526,0.0001876938,0.0002529747,0.0002312153,0.0002134957,0.000749119],"category_scores_gemma":[0.0003195605,0.0001333507,0.000352986,0.0002908008,0.0001399914,0.0001672738,0.0002542585,0.0002965287,0.0002412399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000298682,"about_ca_system_score_gemma":0.0001459676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059806,"about_ca_topic_score_gemma":0.001175019,"domain_scores_codex":[0.9999167,0.00001251051,0.000007724276,0.00002458026,0.00002536149,0.00001303391],"domain_scores_gemma":[0.9998957,0.00002813758,0.00002103711,0.00001913002,0.00002100537,0.00001501435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001607576,0.00002790082,0.004238617,0.00009303093,0.00003629463,0.00008820962,0.00004238006,0.002814891,0.9885118,0.0002463738,0.0001830593,0.003556794],"study_design_scores_gemma":[0.00002356849,0.00026899,0.03290107,0.00001389933,0.00009278652,0.0004823933,0.0001294369,0.06764731,0.8935508,0.0005486585,0.004311807,0.00002930878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929699,0.0002143614,0.004175339,0.00003359729,0.000006129372,0.00001204027,0.001971851,0.0001092671,0.0005074034],"genre_scores_gemma":[0.9880974,0.0001458043,0.007118925,0.00002696468,0.000002009474,0.00001441509,0.004207559,0.00005119063,0.0003357157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059806,"threshold_uncertainty_score":0.002506018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885487901889351,"score_gpt":0.2536384874265248,"score_spread":0.2347836084076313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}