{"id":"W4323543525","doi":"10.1016/j.actbio.2023.03.003","title":"Affinity-controlled release of rod-derived cone viability factor enhances cone photoreceptor survival","year":2023,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Krembil Foundation; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada First Research Excellence Fund; University of Toronto","keywords":"Retinitis pigmentosa; Retina; Viability assay; Biophysics; Retinal; Peptide; Cell biology; Materials science; Biology; Cell; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003111358,0.0002296795,0.0004398455,0.00006326128,0.00007275869,0.00003750309,0.000239204,0.000180143,0.0005056272],"category_scores_gemma":[0.0003384288,0.0001980884,0.0001408942,0.0001678626,0.000176622,0.000008307921,0.0001330261,0.00003008683,0.0000722001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001069087,"about_ca_system_score_gemma":0.00009777471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008742946,"about_ca_topic_score_gemma":0.00002934044,"domain_scores_codex":[0.998499,0.0001677823,0.0004385354,0.0003924192,0.0001911338,0.0003111224],"domain_scores_gemma":[0.9992206,0.0000368874,0.0002028693,0.0003265463,0.0001173257,0.00009577043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001827318,0.00007888364,0.001937023,0.00005993342,0.0001179695,0.000001779523,0.0000880432,1.956791e-7,0.9935685,0.000008230845,0.002195958,0.0001161948],"study_design_scores_gemma":[0.00289772,0.000205475,0.01729307,0.00001131557,0.00001933892,7.770507e-7,0.0001213205,0.000005449012,0.9728925,0.00003741379,0.006271488,0.0002441675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971303,0.00004669761,0.00002226345,0.0001649821,0.001648104,0.0004345046,0.0001682235,0.00005984323,0.0003250995],"genre_scores_gemma":[0.9982386,0.0001651547,0.00009989179,0.00003934172,0.0001385687,0.00005509762,0.0006565857,0.00002396309,0.0005828335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.020676,"threshold_uncertainty_score":0.8077809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412041204569482,"score_gpt":0.2552601454141473,"score_spread":0.2411397333684525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}