{"id":"W4323546612","doi":"10.1038/s41586-023-05720-6","title":"Macrophage fumarate hydratase restrains mtRNA-mediated interferon production","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":224,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institutes of Health; Science Foundation Ireland; National Institute of Allergy and Infectious Diseases; Cedars-Sinai Medical Center; Lupus Research Alliance; Wellcome Trust; U.S. Department of Defense","keywords":"Fumarate reductase; Aconitase; Fumarase; Citric acid cycle; Argininosuccinate synthase; Dimethyl fumarate; Tumor necrosis factor alpha; Chemistry; Biochemistry; Cytokine; Lipopolysaccharide; Biology; Mitochondrion; Succinate dehydrogenase; Immunology; Enzyme; Arginine; Citrulline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002103146,0.0002028316,0.0002280705,0.0001554418,0.0001724174,0.0003653602,0.0001324823,0.0003257267,0.001852304],"category_scores_gemma":[0.0002107202,0.0001302902,0.0002394943,0.00006611403,0.0002313068,0.0001235082,0.0002844333,0.0005388216,0.0005421723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160304,"about_ca_system_score_gemma":0.0002227838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003873389,"about_ca_topic_score_gemma":0.001037651,"domain_scores_codex":[0.9997659,0.00003534804,0.00001580243,0.00004447728,0.00005590086,0.0000824487],"domain_scores_gemma":[0.9998416,0.00004342568,0.00002769314,0.00003026306,0.00001987867,0.0000371549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025895,0.00000884738,0.0001552295,0.00001334128,0.000002050437,0.00002030128,0.000006093713,0.00002108124,0.9989498,0.00004556098,0.00004104187,0.0006341562],"study_design_scores_gemma":[0.00001347888,0.000143607,0.003194458,0.000004345001,0.000005968557,0.00008990665,0.00003109558,0.0003613724,0.9939849,0.00004462705,0.0021239,0.000002351953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891441,0.001716982,0.005448917,0.0003163972,0.0001283135,0.00002876251,0.0004014359,0.0002014062,0.002613721],"genre_scores_gemma":[0.9956545,0.0002747287,0.00108263,0.0000829068,0.00002212849,0.00001862348,0.0002802789,0.000027835,0.002556409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852304,"threshold_uncertainty_score":0.006196558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009521100147193595,"score_gpt":0.2619127002045438,"score_spread":0.2523916000573502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}