{"id":"W4323566638","doi":"10.1101/2023.03.07.531473","title":"Spatial positioning of preimplantation mouse embryo blastomeres is regulated by mTORC1 and 7mG-cap dependent translation at the 8- to 16-cell transition","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministerstvo Školství, Mládeže a Tělovýchovy; Akademie Věd České Republiky; Grantová Agentura České Republiky; Central European Institute of Technology; Jihočeská Univerzita v Českých Budějovicích","keywords":"Blastocyst; Biology; Blastomere; Epiblast; Inner cell mass; Cell biology; PI3K/AKT/mTOR pathway; Embryo; Population; Genetics; Molecular biology; Embryogenesis; Signal transduction; Gastrulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138428,0.0003220175,0.00019938,0.0002381256,0.0001482122,0.0002694971,0.0001890765,0.0002112834,0.001138682],"category_scores_gemma":[0.000092912,0.0002421287,0.0001786421,0.0000749215,0.0001699967,0.0001205317,0.0002339477,0.0004066508,0.0006287858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266831,"about_ca_system_score_gemma":0.0001570114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004698609,"about_ca_topic_score_gemma":0.0009162949,"domain_scores_codex":[0.9998809,0.00001167989,0.00001218781,0.00003460544,0.000031113,0.00002947305],"domain_scores_gemma":[0.9998808,0.00001109093,0.00004864114,0.000008547934,0.00001360676,0.00003730484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006873387,0.000005302042,0.000176333,0.0000194032,0.00000140677,0.00002951173,0.000007925043,0.00002379435,0.999095,0.00006165514,0.00002181097,0.0004891813],"study_design_scores_gemma":[0.000009805832,0.000175613,0.01933887,0.00001082863,0.000009652141,0.0001194399,0.00002349523,0.0004751777,0.9774878,0.00003126635,0.002314587,0.000003425336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932095,0.001800956,0.001866641,0.00004127854,0.00002479632,0.00002865357,0.000589214,0.0001253513,0.002313643],"genre_scores_gemma":[0.9904301,0.0009702581,0.002156641,0.0000359499,0.00001315408,0.00006507637,0.0009833809,0.00004174965,0.005303728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001138682,"threshold_uncertainty_score":0.003809273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214750870030077,"score_gpt":0.230304891455853,"score_spread":0.2181573827555522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}