{"id":"W4323567071","doi":"10.3389/fonc.2023.1111191","title":"Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Hospitalier Universitaire de Sherbrooke; Université de Montréal; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; Jewish General Hospital; Montreal Neurological Institute and Hospital; McGill Genome Centre; Université de Sherbrooke; University of Toronto; University Health Network; Centre Hospitalier de l’Université de Montréal; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Ovarian Cancer Canada; Cancer Research Society; McGill University","keywords":"Candidate gene; Genetics; Biology; Gene; Population; Cancer; Allele; Ovarian cancer; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004991899,0.00018985,0.0002729742,0.001487711,0.0003974076,0.0003787043,0.00017123,0.0002788505,0.001359037],"category_scores_gemma":[0.0019279,0.0001301036,0.0003262289,0.001073269,0.0003099887,0.0001354422,0.0003470911,0.0001742016,0.0001058787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002132111,"about_ca_system_score_gemma":0.0001972683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00324042,"about_ca_topic_score_gemma":0.003801309,"domain_scores_codex":[0.9995841,0.00005908444,0.00005908089,0.0001323219,0.0000918229,0.00007348137],"domain_scores_gemma":[0.9994426,0.0001841574,0.0001755129,0.00007245038,0.00005255693,0.00007272451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003733795,0.00002262259,0.9663187,0.00002702201,0.00009442273,0.001976595,0.0003249139,0.0002092013,0.02418308,0.0001787635,0.00007280839,0.006218499],"study_design_scores_gemma":[0.000009564258,0.00006175141,0.9933101,0.000006753553,0.00007263504,0.003709368,0.0001431586,0.0004603848,0.001733032,0.0001236305,0.0003649302,0.000004615179],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994604,0.00009115197,0.0001448776,0.000006162369,8.971226e-7,0.000004290734,0.00007061031,0.000003040228,0.0002185063],"genre_scores_gemma":[0.9994585,0.0000610209,0.0002464046,0.000007330993,0.000002194931,0.000003079159,0.0001338929,0.000002764966,0.00008484865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00324042,"threshold_uncertainty_score":0.006443083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03958137678874124,"score_gpt":0.3530134367413027,"score_spread":0.3134320599525615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}