{"id":"W4323567711","doi":"10.3389/fphar.2023.1118580","title":"Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-brain barrier integrity and function","year":2023,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto; Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Dolutegravir; Efavirenz; Ex vivo; Blood–brain barrier; Immunology; Reverse-transcriptase inhibitor; Pharmacology; Integrase inhibitor; Medicine; Virology; Biology; In vivo; Viral load; Virus; Internal medicine; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007580161,0.0001943671,0.0001793107,0.000165865,0.0001826693,0.0003091201,0.0001067071,0.0001891515,0.0006497366],"category_scores_gemma":[0.00008718907,0.00007829112,0.0001509915,0.0001240574,0.0001535656,0.0002028995,0.00009838513,0.0003294874,0.000114996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002288723,"about_ca_system_score_gemma":0.0001460863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059792,"about_ca_topic_score_gemma":0.001959209,"domain_scores_codex":[0.9998621,0.00002771656,0.00001266144,0.00002428115,0.00004092912,0.00003239764],"domain_scores_gemma":[0.9999659,0.000004964691,0.00001140124,0.000003519419,0.000007874278,0.000006280179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001867007,0.00003541158,0.001227554,0.00009815466,0.00001733327,0.00009771503,0.00003058036,0.0001080813,0.9910402,0.0001746037,0.00008961868,0.006894086],"study_design_scores_gemma":[0.0000347646,0.0008249917,0.06584673,0.00003860522,0.00006134727,0.001049801,0.0001655079,0.001787608,0.9200488,0.0002081054,0.009921095,0.00001278724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884089,0.008220433,0.001109228,0.0001197027,0.00002404088,0.00001380213,0.0002914925,0.00004502093,0.001767261],"genre_scores_gemma":[0.9950905,0.002772993,0.0007159862,0.00005915635,0.000005741573,0.00001666986,0.0002016233,0.000004469495,0.001132982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059792,"threshold_uncertainty_score":0.002173603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025420352076718,"score_gpt":0.2723173813197038,"score_spread":0.2620631777989367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}