{"id":"W4323569136","doi":"10.1101/2023.03.04.531108","title":"MerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microglia","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Child Health and Human Development; Fonds de Recherche du Québec - Santé; Canada First Research Excellence Fund; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Verily Life Sciences; Québec Consortium for Drug Discovery; Canadian Institutes of Health Research; Compute Canada; McGill University; Pfizer; Celgene; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Sanofi; Michael J. Fox Foundation for Parkinson's Research; Foundation for the National Institutes of Health","keywords":"MERTK; Microglia; Dementia with Lewy bodies; Synucleinopathies; Internalization; Cell biology; Biology; Alpha-synuclein; Parkinson's disease; Receptor; Immunology; Pathology; Receptor tyrosine kinase; Signal transduction; Medicine; Dementia; Disease; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398385,0.00023123,0.0002210719,0.0001334233,0.0001697247,0.0003457615,0.0001099427,0.0002457157,0.001169285],"category_scores_gemma":[0.0001640213,0.0000942616,0.0002599117,0.00009947737,0.00009955082,0.0001596275,0.0002117012,0.0002186953,0.0005650481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254705,"about_ca_system_score_gemma":0.0001197345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005008397,"about_ca_topic_score_gemma":0.0004354155,"domain_scores_codex":[0.9998618,0.00002724324,0.00001260111,0.00003139538,0.00003069225,0.00003615675],"domain_scores_gemma":[0.999927,0.00001390043,0.00001568718,0.00001220408,0.00001896246,0.00001216796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002729245,0.00002198644,0.0007245239,0.00003585614,0.000006118575,0.0001082508,0.00003360377,0.00003404482,0.9976573,0.00003492603,0.00004261463,0.001027892],"study_design_scores_gemma":[0.00006841136,0.0008195596,0.05364632,0.00002393168,0.00004622742,0.001807303,0.0001862526,0.002225083,0.93831,0.0001784089,0.002678199,0.00001032725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968706,0.001304904,0.0009342456,0.0000353979,0.00001285955,0.00001468746,0.0001924502,0.00001845196,0.0006165028],"genre_scores_gemma":[0.9980103,0.0003588789,0.0005207745,0.00002719804,0.000006209567,0.00001615027,0.0002516829,0.000004426888,0.0008044292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001169285,"threshold_uncertainty_score":0.003911674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03836918554788202,"score_gpt":0.2450702134088825,"score_spread":0.2067010278610004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}