{"id":"W4323569487","doi":"10.1002/ange.202218698","title":"The Self‐Association of the KRAS4b Protein is Altered by Lipid‐Bilayer Composition and Electrostatics","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Gyeonggi-do Regional Research Center; Canada Foundation for Innovation; Princess Margaret Cancer Foundation","keywords":"Dimer; Chemistry; KRAS; Lipid bilayer; Biophysics; Electrostatics; Phosphatidylcholine; Peripheral membrane protein; Membrane; Effector; Nanodisc; Phosphatidylserine; Static electricity; Bilayer; Membrane protein; Cell biology; Biochemistry; Integral membrane protein; Mutation; Biology; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128579,0.0001332778,0.00009073419,0.0001245129,0.0001529794,0.0002190804,0.0001488131,0.0001545207,0.001119307],"category_scores_gemma":[0.0001637872,0.0001091122,0.0001137983,0.0001067318,0.0001627825,0.0001590429,0.000174317,0.0002735083,0.000246962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456743,"about_ca_system_score_gemma":0.0001154979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006056089,"about_ca_topic_score_gemma":0.0004881016,"domain_scores_codex":[0.9999136,0.00001516425,0.000006003956,0.00001825088,0.00002740319,0.00001958302],"domain_scores_gemma":[0.9999295,0.0000138349,0.00001921144,0.000005445132,0.00001177067,0.00002015244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005828344,0.00001388457,0.000182322,0.000009044216,0.000004474211,0.00001469377,0.00001330966,0.00005076959,0.9991918,0.0000731652,0.00002183042,0.0003663318],"study_design_scores_gemma":[0.000009270076,0.00005171226,0.002912324,0.00000256842,0.000005347016,0.00007446573,0.00004040871,0.002826093,0.9935734,0.00005095786,0.0004478635,0.000005645151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988332,0.00008957273,0.0005820791,0.00002869928,0.000005700073,0.000003111111,0.00004841229,0.00001328747,0.0003958526],"genre_scores_gemma":[0.9991628,0.0000524535,0.000324228,0.00001580703,9.833334e-7,0.000003458545,0.00005108818,0.000005335618,0.0003839303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119307,"threshold_uncertainty_score":0.003744483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005558479460331862,"score_gpt":0.227904737436934,"score_spread":0.2223462579766022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}