{"id":"W4323652592","doi":"10.1007/s00415-023-11633-1","title":"Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1","year":2023,"lang":"en","type":"article","venue":"Journal of Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi; Université de Sherbrooke; Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Daiichi Sankyo Europe; Abbott Vascular; Servier; Canadian Institutes of Health Research; Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.; Deutsche Herzstiftung; AFM-Téléthon; Abiomed; Vifor Pharma; National Institute for Health Research Health Protection Research Unit; ReCor Medical; Boston Scientific Corporation; Esperion Therapeutics; Deutsche Forschungsgemeinschaft; Deutsche Gesellschaft für Muskelkranke; Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen; Amgen; Edwards Lifesciences; Canada Research Chairs; AstraZeneca","keywords":"Periostin; Medicine; Myotonic dystrophy; Biomarker; Cardiomyopathy; Neurology; Fibrosis; Pathology; Internal medicine; Disease; Cardiology; Heart failure; Biology; Genetics; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005446759,0.0004195289,0.0005521438,0.0007240043,0.0003133394,0.0007538024,0.0002375673,0.0008298284,0.0007706595],"category_scores_gemma":[0.001093446,0.0002138035,0.0002106714,0.0004895334,0.0002830421,0.0003999635,0.000331995,0.0006484761,0.0001644054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661486,"about_ca_system_score_gemma":0.0001553256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006979051,"about_ca_topic_score_gemma":0.001065938,"domain_scores_codex":[0.9997173,0.00008315354,0.00002522931,0.00007747082,0.00006186552,0.00003492233],"domain_scores_gemma":[0.999391,0.0001659168,0.0002198657,0.00002537466,0.00005714191,0.0001407653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005200901,0.0002345714,0.9395857,0.00009152991,0.0001797464,0.000643726,0.0002357036,0.0003438913,0.03973475,0.0001088436,0.0003252715,0.01331538],"study_design_scores_gemma":[0.000043331,0.00074333,0.9929157,0.00002338988,0.00009582739,0.001176277,0.0001541088,0.00166366,0.002690097,0.0001528364,0.0003264082,0.0000149086],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977493,0.001153575,0.0002724656,0.00005210815,0.00001705616,0.000009314223,0.0001437821,0.0000142777,0.0005882084],"genre_scores_gemma":[0.9986787,0.0001706822,0.0004048011,0.00004513424,0.00002155288,0.00001269415,0.0001431304,0.000002774586,0.0005205183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008298284,"threshold_uncertainty_score":0.002880573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955093157838819,"score_gpt":0.2567626182830806,"score_spread":0.2372116867046924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}