{"id":"W4323652962","doi":"10.1002/eji.202250002","title":"Targeting regulatory T cell metabolism in disease: Novel therapeutic opportunities","year":2023,"lang":"en","type":"review","venue":"European Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Autoimmunity; Cell metabolism; Immune system; Adoptive cell transfer; Function (biology); Cancer research; Regulatory T cell; Cancer; Immunology; Transplant rejection; T cell; Cell; Cell biology; Genetics; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005882527,0.0007281236,0.001089808,0.001114876,0.0002169748,0.0008909183,0.000732709,0.001274042,0.002632861],"category_scores_gemma":[0.0003913848,0.0002132608,0.000429624,0.0008738143,0.0004319481,0.001193023,0.0005986234,0.002554302,0.001581162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004928154,"about_ca_system_score_gemma":0.0006459783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003554678,"about_ca_topic_score_gemma":0.0008157884,"domain_scores_codex":[0.999872,0.00002652283,0.00001362464,0.0000219895,0.0000469612,0.0000190041],"domain_scores_gemma":[0.999848,0.00007335407,0.00001706652,0.000005631242,0.00003356226,0.0000223662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001312687,0.0001118929,0.0001081058,0.009050213,0.0000738833,0.0002172537,0.00005165023,0.0004897438,0.004948134,0.007546636,0.02781225,0.9494589],"study_design_scores_gemma":[0.00003565158,0.0001738963,0.0003858361,0.001786249,0.00007320793,0.000911772,0.00003666967,0.0001353474,0.0006932811,0.00308257,0.9926699,0.00001547435],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001645215,0.9978213,0.0002611061,0.0005250554,0.0003193877,0.000004531525,0.00001274433,0.00001264715,0.0008787072],"genre_scores_gemma":[0.001022556,0.9971908,0.0003295875,0.0004522844,0.0003023903,0.00001103791,0.00002925568,0.000002432621,0.0006597086],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002632861,"threshold_uncertainty_score":0.008807778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1625902592490304,"score_gpt":0.3537250928782405,"score_spread":0.19113483362921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}