{"id":"W4323653185","doi":"10.1007/s13555-023-00913-3","title":"Efficacy and Safety of Risankizumab for the Treatment of Hidradenitis Suppurativa: A Phase 2, Randomized, Placebo-Controlled Trial","year":2023,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Hidradenitis Suppurativa and Treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Dalhousie University","funders":"AbbVie","keywords":"Medicine; Placebo; Adverse effect; Internal medicine; Randomized controlled trial; Discontinuation; Clinical endpoint","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002303365,0.0001964587,0.001362317,0.0001147057,0.0001516788,0.000006463664,0.00004068449,0.0001172031,0.00005318],"category_scores_gemma":[0.00008898851,0.0001020075,0.0002417637,0.0001122964,0.0004610148,0.00003966066,0.000006760286,0.00004938021,0.000002128527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009717312,"about_ca_system_score_gemma":0.0000583016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001743069,"about_ca_topic_score_gemma":0.000003168617,"domain_scores_codex":[0.9987664,0.0002537374,0.0005018763,0.0001901913,0.00009776127,0.0001900516],"domain_scores_gemma":[0.9956044,0.003934375,0.0001780828,0.0001790816,0.0000438346,0.00006023954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9660618,0.001026819,0.0001345166,0.00002608903,0.002001278,0.0007434636,0.002520022,6.897238e-8,0.0002331091,0.0007610943,0.00007231756,0.02641947],"study_design_scores_gemma":[0.9841345,0.002873143,0.00008435866,0.00002262633,0.0005946984,0.006460376,0.0001858274,0.0003920251,0.003301936,0.000427705,0.001446222,0.00007657044],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731405,0.005934002,0.0001327854,0.01125196,0.0001559686,0.00911943,0.00006798447,0.00003485442,0.0001625483],"genre_scores_gemma":[0.9806286,0.01781457,0.00005791628,0.000008643242,0.00004972015,0.001124271,0.00006778094,0.00001529643,0.0002332583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0263429,"threshold_uncertainty_score":0.4159745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630794866463905,"score_gpt":0.3333459065778167,"score_spread":0.3070379579131776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}