{"id":"W4323656721","doi":"10.1073/pnas.2216901120","title":"Visualizing cell–cell communication using synthetic notch activated MRI","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Institute of Cancer Research; Ontario Institute for Cancer Research; Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cancer cell; CD19; Biology; Cell biology; Cell; Antigen; Immune system; Reporter gene; Cancer research; Bioluminescence imaging; Cell culture; Cancer; Immunology; Gene expression; Gene; Biochemistry; Genetics; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002192091,0.00008862244,0.0001749255,0.000365465,0.0002505089,0.00002615305,0.0006671715,0.00008845685,0.0001091985],"category_scores_gemma":[0.0003516544,0.00006340556,0.00008579552,0.002087894,0.0006877621,0.000258175,0.0002400143,0.0002714344,0.000008254241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008863542,"about_ca_system_score_gemma":0.00007710515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002247726,"about_ca_topic_score_gemma":3.511874e-8,"domain_scores_codex":[0.9977143,0.0000159291,0.0002965333,0.0002147937,0.001551572,0.0002068795],"domain_scores_gemma":[0.9989937,0.0002744918,0.000286236,0.00002005577,0.0003777585,0.0000477827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003725383,0.00005498363,0.003333096,0.0001300536,0.000009932008,8.824396e-9,0.0003310542,0.0001077727,0.9943448,0.001007044,0.000399912,0.000244052],"study_design_scores_gemma":[0.0003154566,0.00004395621,0.008879561,0.0001977811,0.00001760908,0.000007371299,0.000589505,0.009157445,0.9769195,0.003442764,0.0003655207,0.00006355219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798673,0.0001179681,7.796941e-7,0.002824515,0.00001092726,0.0002944088,0.000003668246,0.00003157282,0.01684885],"genre_scores_gemma":[0.997261,0.0001426731,0.00108069,0.0001272703,0.00004172647,0.000006221463,3.760583e-7,0.000009771892,0.001330228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01742536,"threshold_uncertainty_score":0.2585604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1177983492707031,"score_gpt":0.4075851612719628,"score_spread":0.2897868120012598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}