{"id":"W4323656721","doi":"10.1073/pnas.2216901120","title":"Visualizing cell–cell communication using synthetic notch activated MRI","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Institute of Cancer Research; Ontario Institute for Cancer Research; Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cancer cell; CD19; Biology; Cell biology; Cell; Antigen; Immune system; Reporter gene; Cancer research; Bioluminescence imaging; Cell culture; Cancer; Immunology; Gene expression; Gene; Biochemistry; Genetics; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058933,0.0002896606,0.0001180998,0.0001888288,0.0000934609,0.0002977262,0.0003685826,0.0004874002,0.001351504],"category_scores_gemma":[0.0001905314,0.000145878,0.0001282708,0.000126166,0.0002476483,0.0003014475,0.000327255,0.0004247022,0.0003217496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485797,"about_ca_system_score_gemma":0.0001311568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002172072,"about_ca_topic_score_gemma":0.0003136371,"domain_scores_codex":[0.9998957,0.00002402882,0.00000483347,0.00003060183,0.00002639455,0.00001849548],"domain_scores_gemma":[0.9998868,0.00004272302,0.00003559742,0.000009357707,0.00001020784,0.00001522893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002554736,0.000006389752,0.00002254809,0.00003010323,0.000001594881,0.00003907756,0.00001151847,0.0002437073,0.9982176,0.0003073524,0.00004858497,0.001045838],"study_design_scores_gemma":[0.00002357346,0.0002196761,0.0004088334,0.000008445551,0.000006733355,0.000220398,0.00002614859,0.008111848,0.9862884,0.0003026068,0.00437397,0.000009422412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8873402,0.00220433,0.09905092,0.0005911427,0.0001025049,0.0001241605,0.0003880961,0.0004331181,0.009765555],"genre_scores_gemma":[0.9285045,0.001390436,0.0646743,0.0002688277,0.00003597726,0.0001511449,0.000285792,0.0000459387,0.004643179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351504,"threshold_uncertainty_score":0.004521251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1177983492707031,"score_gpt":0.4075851612719628,"score_spread":0.2897868120012598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}