{"id":"W4323804541","doi":"10.15252/msb.202211024","title":"Phosphorylation‐linked complex profiling identifies assemblies required for Hippo signal integration","year":2023,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Branco Weiss Fellowship – Society in Science; Marie Curie; European Federation of Pharmaceutical Industries and Associations; European Molecular Biology Organization; McGill University; Francis Crick Institute","keywords":"YAP1; Phosphorylation; Biology; Hippo signaling pathway; Protein phosphorylation; Cell biology; Computational biology; Immunoprecipitation; Phosphoproteomics; Protein–protein interaction; Phosphorylation cascade; Signal transduction; Biochemistry; Protein kinase A; Transcription factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000167984,0.0004082007,0.0003436427,0.0006085534,0.0002785338,0.0006350792,0.0002236101,0.0002529636,0.0008275246],"category_scores_gemma":[0.0004872511,0.000320965,0.0003620445,0.0003720082,0.0002117262,0.000590038,0.0003664669,0.0002929259,0.0002647937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004577817,"about_ca_system_score_gemma":0.0002029986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150785,"about_ca_topic_score_gemma":0.002217818,"domain_scores_codex":[0.9999015,0.00001056122,0.000009911852,0.00003982772,0.00002272375,0.00001536862],"domain_scores_gemma":[0.9998329,0.00004025345,0.00006276072,0.00001493917,0.00001702284,0.00003209897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003881302,0.00004725409,0.01245633,0.0001469664,0.00007839327,0.000138903,0.00007016493,0.01219232,0.9667096,0.001062911,0.000254427,0.006454617],"study_design_scores_gemma":[0.00004435582,0.0001745206,0.08687677,0.00001305477,0.0001164897,0.0002851089,0.0001184459,0.3644169,0.5442411,0.001992524,0.001674226,0.00004642814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870596,0.0002276193,0.01167818,0.00002696482,0.000002666873,0.00001662154,0.0004197576,0.0001376998,0.0004309009],"genre_scores_gemma":[0.9877124,0.0001757762,0.01063608,0.00001023421,0.000001831297,0.00001887662,0.001178871,0.00005391672,0.0002118855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001150785,"threshold_uncertainty_score":0.003321409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04453826619671372,"score_gpt":0.3038134096610474,"score_spread":0.2592751434643337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}