{"id":"W4323808406","doi":"10.1080/10717544.2023.2186312","title":"Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors","year":2023,"lang":"en","type":"article","venue":"Drug Delivery","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of British Columbia","funders":"Iran Science Elites Federation","keywords":"Drug delivery; Drug; Nanoparticle; Bioavailability; Materials science; Doxorubicin; Nanotechnology; Distribution (mathematics); Targeted drug delivery; Drug carrier; Biomedical engineering; Pharmacology; Medicine; Chemotherapy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008643368,0.0002011988,0.0001406388,0.0001001404,0.00006503195,0.0001491476,0.0001980072,0.0002052962,0.0004019136],"category_scores_gemma":[0.0001426486,0.0001226871,0.0002059638,0.000076388,0.0001374532,0.0002601626,0.0001584539,0.0002045763,0.0001317805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002823747,"about_ca_system_score_gemma":0.0001590825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003411083,"about_ca_topic_score_gemma":0.0005710541,"domain_scores_codex":[0.9999576,0.000004606437,0.000002681893,0.00001141699,0.00001631242,0.000007456306],"domain_scores_gemma":[0.9999514,0.00001547419,0.0000189699,0.000003739879,0.000005366569,0.000005130514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001701013,0.00002043258,0.00006041171,0.00003974741,0.000002736254,0.0000336701,0.000008709409,0.004463787,0.9916365,0.0005897604,0.00005860963,0.003068576],"study_design_scores_gemma":[0.00002039221,0.0001666514,0.0005183178,0.000004589077,0.00001195603,0.0001015266,0.000006062426,0.1169858,0.8788406,0.0002905288,0.003040923,0.00001268712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8219546,0.002412991,0.1707727,0.0002504551,0.0001086342,0.0001276564,0.0001319804,0.0005558056,0.003685166],"genre_scores_gemma":[0.9722863,0.0007398131,0.02525642,0.00008261008,0.00001735003,0.00008193561,0.00004202864,0.00002607615,0.001467356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004019136,"threshold_uncertainty_score":0.00204879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04125121701118707,"score_gpt":0.3104379311773716,"score_spread":0.2691867141661846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}