{"id":"W4323823189","doi":"10.6004/jnccn.2022.7097","title":"Evaluating Germline Testing Panels in Southern African Males With Advanced Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Journal of the National Comprehensive Cancer Network","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"DOD Prostate Cancer Research Program; South African Medical Research Council; Medical Research Council; University of Sydney; Cancer Association of South Africa; National Health and Medical Research Council; Johns Hopkins University","keywords":"Prostate cancer; CHEK2; Germline; Medicine; Genetic testing; Cancer; Family history; Oncology; PALB2; Germline mutation; Disease; Internal medicine; Genetics; Gene; Mutation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003125251,0.0001897413,0.0004092874,0.0001299196,0.00013773,0.00002328515,0.000142178,0.00003875035,0.00003961216],"category_scores_gemma":[0.0001752755,0.0001132777,0.000112378,0.001253236,0.00007916747,0.00009231865,0.00006194794,0.0003487025,0.00000402482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000687892,"about_ca_system_score_gemma":0.0008301403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007677169,"about_ca_topic_score_gemma":0.00007306971,"domain_scores_codex":[0.9979614,0.00009972378,0.0005103634,0.0002029713,0.0008902734,0.000335273],"domain_scores_gemma":[0.9966863,0.0005226378,0.0006748185,0.0001036807,0.001915519,0.00009703975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.001055993,0.00007414637,0.2498011,0.00008211668,0.0003086088,0.00006454052,0.001106086,0.7211644,0.001896616,0.00001580919,0.001398958,0.02303159],"study_design_scores_gemma":[0.006885577,0.001042472,0.9668205,0.005744759,0.0003061742,0.0001466167,0.001352791,0.0113176,0.000569555,0.001248253,0.004268186,0.0002974757],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851156,0.006899963,0.000003593985,0.0067489,0.0004279692,0.0005805996,0.00006923269,0.0000214033,0.0001327301],"genre_scores_gemma":[0.9947725,0.001021649,0.00134727,0.001255593,0.001054735,0.0001685606,0.000006258618,0.00003689329,0.0003365273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7170194,"threshold_uncertainty_score":0.461933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1261633666245778,"score_gpt":0.3897793406714649,"score_spread":0.2636159740468871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}