{"id":"W4323823189","doi":"10.6004/jnccn.2022.7097","title":"Evaluating Germline Testing Panels in Southern African Males With Advanced Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Journal of the National Comprehensive Cancer Network","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"DOD Prostate Cancer Research Program; South African Medical Research Council; Medical Research Council; University of Sydney; Cancer Association of South Africa; National Health and Medical Research Council; Johns Hopkins University","keywords":"Prostate cancer; CHEK2; Germline; Medicine; Genetic testing; Cancer; Family history; Oncology; PALB2; Germline mutation; Disease; Internal medicine; Genetics; Gene; Mutation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006141227,0.0004243107,0.0001962264,0.001074005,0.0005619842,0.0004092757,0.0001992867,0.0003282158,0.001522158],"category_scores_gemma":[0.001972614,0.0001476201,0.0002426695,0.0008723759,0.0003559556,0.0001946412,0.0005119084,0.000233947,0.0001857601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002749284,"about_ca_system_score_gemma":0.0003429972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004167633,"about_ca_topic_score_gemma":0.006190464,"domain_scores_codex":[0.9996959,0.00008027865,0.00001885688,0.00007270534,0.00007147174,0.00006076271],"domain_scores_gemma":[0.9994988,0.0002281313,0.000150953,0.0000205554,0.00004642053,0.00005500418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002068761,0.00002293764,0.9816281,0.00004718354,0.00004419091,0.001583754,0.0005913242,0.0006685524,0.005346744,0.0001050799,0.0001708419,0.009584446],"study_design_scores_gemma":[0.00002053232,0.0003118146,0.9761127,0.00008584114,0.0001524971,0.007912652,0.001628068,0.005539508,0.005456531,0.000556322,0.002207347,0.00001625347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991521,0.0002460361,0.0002131772,0.00004803245,0.000002293555,0.000006247594,0.00009785099,0.000007783684,0.0002265832],"genre_scores_gemma":[0.9991449,0.0001295721,0.0005070161,0.00002907566,0.000003817834,0.000003443141,0.0001287754,0.000003261377,0.00005018336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004167633,"threshold_uncertainty_score":0.008286774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1261633666245778,"score_gpt":0.3897793406714649,"score_spread":0.2636159740468871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}