{"id":"W4323843760","doi":"10.3390/antiox12030674","title":"Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles","year":2023,"lang":"en","type":"article","venue":"Antioxidants","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Canadian Nuclear Laboratories; McGill University Health Centre","funders":"","keywords":"Bioenergetics; Biology; Cell biology; Mitochondrion; Oxidative stress; Circadian rhythm; Oxidative phosphorylation; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003841065,0.0002063051,0.0003537383,0.0002001634,0.0001886299,0.00006036866,0.0001064888,0.000162547,0.00000387926],"category_scores_gemma":[0.0003208183,0.0001517038,0.00005187391,0.0005857843,0.0006057454,0.0001755881,0.00006775399,0.0001707873,0.00000209402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007045005,"about_ca_system_score_gemma":0.00003974653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008120727,"about_ca_topic_score_gemma":0.00002496699,"domain_scores_codex":[0.9985178,0.0001311587,0.0004197066,0.0004169886,0.0002262184,0.0002881659],"domain_scores_gemma":[0.998984,0.0002854398,0.0002756882,0.0002721146,0.00007158075,0.0001112173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009504693,0.00001398151,0.007382497,0.00007415027,0.00001571234,0.000008698498,0.001167119,0.00007170158,0.9872516,0.003310008,0.0000132903,0.0005962361],"study_design_scores_gemma":[0.001395274,0.00006858741,0.08115117,0.0002161525,0.00002546109,0.00004943078,0.0006236788,0.005600325,0.9091187,0.001462568,0.0001139347,0.0001747314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962888,0.002481104,0.000003804878,0.0003020728,0.0001337743,0.0005690472,0.00007615103,0.00006217851,0.00008306094],"genre_scores_gemma":[0.9984325,0.00121584,0.00007206221,0.00003388721,0.00007946206,0.00001704067,0.00001351576,0.00002903547,0.0001066822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07813287,"threshold_uncertainty_score":0.6186301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009609083350240686,"score_gpt":0.2152370977335714,"score_spread":0.2056280143833307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}