{"id":"W4323854285","doi":"10.21203/rs.3.rs-2667175/v1","title":"Bioproduction platform using a novel cane toad (Rhinella marina) N-methyltransferase for psychedelic-inspired drug discovery","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Directorate for Biological Sciences; University of Calgary","keywords":"Bioproduction; Drug discovery; Toad; Cane; Biology; Pharmacology; Ecology; Biotechnology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472687,0.0005428883,0.000379844,0.0002859759,0.0002343665,0.0004227142,0.0004243157,0.0006498258,0.001882722],"category_scores_gemma":[0.0002259015,0.0001851138,0.0006906023,0.0002041449,0.0002159103,0.0002869274,0.0005023082,0.0007992731,0.001249528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002065341,"about_ca_system_score_gemma":0.0003056906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006490963,"about_ca_topic_score_gemma":0.001153693,"domain_scores_codex":[0.9998338,0.00001360521,0.000008405656,0.00005676511,0.00005883175,0.00002843922],"domain_scores_gemma":[0.9999139,0.000010279,0.00001684284,0.00001526836,0.00002039897,0.0000233174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005613109,0.00003703835,0.000071122,0.00005609749,0.00001681157,0.00004847648,0.000009616508,0.0001547699,0.9942728,0.0001809844,0.0001503153,0.004945782],"study_design_scores_gemma":[0.00001436423,0.0002252311,0.0003260705,0.000005853399,0.00002569105,0.00009352604,0.000009381399,0.00103927,0.9925404,0.00007036882,0.005635926,0.00001394272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8095095,0.005060705,0.1601152,0.0008715363,0.0009018065,0.0006902699,0.002275072,0.0026735,0.01790242],"genre_scores_gemma":[0.8770691,0.002395938,0.09664582,0.0004039655,0.00006052534,0.0002948247,0.001771979,0.0001915231,0.02116625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001882722,"threshold_uncertainty_score":0.006298363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3418403077517411,"score_gpt":0.5004722710443215,"score_spread":0.1586319632925804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}