{"id":"W4323854285","doi":"10.21203/rs.3.rs-2667175/v1","title":"Bioproduction platform using a novel cane toad (Rhinella marina) N-methyltransferase for psychedelic-inspired drug discovery","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Directorate for Biological Sciences; University of Calgary","keywords":"Bioproduction; Drug discovery; Toad; Cane; Biology; Pharmacology; Ecology; Biotechnology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004018,0.0007712021,0.001011907,0.001305479,0.000885476,0.000458535,0.0009988932,0.0007314715,0.0001149049],"category_scores_gemma":[0.0005516137,0.0007452431,0.0006572084,0.001167194,0.0003955881,0.000214735,0.001094679,0.002079766,0.0001783022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006630566,"about_ca_system_score_gemma":0.0005482892,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02067903,"about_ca_topic_score_gemma":0.002346169,"domain_scores_codex":[0.9931394,0.0002351292,0.0009265342,0.002411148,0.001371305,0.001916502],"domain_scores_gemma":[0.9953988,0.000802465,0.0002233901,0.002099921,0.001151906,0.0003234949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01723371,0.01435873,0.03605806,0.03745451,0.01485722,0.0006558059,0.07521342,0.01409514,0.0775402,0.1104277,0.516552,0.08555351],"study_design_scores_gemma":[0.04389502,0.005106387,0.1361755,0.01736878,0.002156678,0.0004129076,0.1240747,0.03101988,0.01038569,0.2295025,0.3807526,0.01914934],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9350442,0.004184839,0.01860924,0.01127873,0.01213692,0.007666471,0.005053999,0.0006495162,0.005376039],"genre_scores_gemma":[0.9570691,0.001331095,0.003117641,0.0001238192,0.004826188,0.003540442,0.001340671,0.000483137,0.02816788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1357993,"threshold_uncertainty_score":0.9994999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3418403077517411,"score_gpt":0.5004722710443215,"score_spread":0.1586319632925804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}