{"id":"W4323920815","doi":"10.1002/advs.202300311","title":"Synthetic Ionizable Colloidal Drug Aggregates Enable Endosomal Disruption","year":2023,"lang":"en","type":"article","venue":"Advanced Science","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Natural Sciences and Engineering Research Council of Canada; University of Toronto; Austrian Science Fund","keywords":"Phospholipidosis; Endosome; Chemistry; Drug; Lysosome; Fulvestrant; Endocytosis; Biophysics; Colloid; Pharmacology; Biochemistry; Phospholipid; Cancer; Membrane; Enzyme; Biology; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001592555,0.0003208203,0.0001341271,0.000158562,0.000124943,0.0002593664,0.0001755163,0.0002731908,0.0004991483],"category_scores_gemma":[0.0001986585,0.0001297492,0.0001391873,0.00009832651,0.0002894985,0.0002102224,0.0002320634,0.0003037766,0.0001653884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003330647,"about_ca_system_score_gemma":0.0001827867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003066755,"about_ca_topic_score_gemma":0.0003648912,"domain_scores_codex":[0.9998932,0.00002030546,0.00001401074,0.00002595058,0.00002824037,0.00001826886],"domain_scores_gemma":[0.9998641,0.00002216659,0.00005660518,0.0000136424,0.00002191116,0.00002148232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001886097,0.000006551699,0.00002608113,0.00001220235,0.000001634732,0.00001120074,0.00000605777,0.00007690047,0.9994376,0.00008120031,0.00001022069,0.0003113418],"study_design_scores_gemma":[0.000006046282,0.0000733056,0.0001605717,9.393623e-7,0.00000272293,0.00002331335,0.000003304853,0.0003106136,0.9988778,0.00001741553,0.0005219216,0.000002051463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893778,0.0005647081,0.008029511,0.00006805154,0.00002611613,0.0000516538,0.0001208938,0.00008906169,0.001672211],"genre_scores_gemma":[0.9933921,0.0002416493,0.005467432,0.00003868425,0.000003960319,0.00003043517,0.00009548537,0.0000148326,0.0007154342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004991483,"threshold_uncertainty_score":0.002416611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006533592571320737,"score_gpt":0.2596396434866458,"score_spread":0.253106050915325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}