{"id":"W4323920815","doi":"10.1002/advs.202300311","title":"Synthetic Ionizable Colloidal Drug Aggregates Enable Endosomal Disruption","year":2023,"lang":"en","type":"article","venue":"Advanced Science","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Natural Sciences and Engineering Research Council of Canada; University of Toronto; Austrian Science Fund","keywords":"Phospholipidosis; Endosome; Chemistry; Drug; Lysosome; Fulvestrant; Endocytosis; Biophysics; Colloid; Pharmacology; Biochemistry; Phospholipid; Cancer; Membrane; Enzyme; Biology; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156924,0.0001187408,0.0000934291,0.0000778016,0.0003227098,0.00004841097,0.0003234312,0.00004323755,0.00002415617],"category_scores_gemma":[0.0001440082,0.000102409,0.00004585326,0.000662863,0.0003155866,0.00002653515,0.0001495175,0.0000629702,0.00007592075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000191045,"about_ca_system_score_gemma":0.0001229239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009731598,"about_ca_topic_score_gemma":0.00001383126,"domain_scores_codex":[0.9987077,0.00001539445,0.0001211428,0.0004850817,0.0002439992,0.000426657],"domain_scores_gemma":[0.9994021,0.00001011594,0.00004986818,0.0003487584,0.00008360983,0.0001055444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001065651,0.00001156663,0.0003951412,0.000005670227,0.000001732246,0.000004088521,0.00003751244,0.0005010663,0.993539,0.00007443966,0.000156034,0.005263091],"study_design_scores_gemma":[0.0002401307,0.00006055359,0.000603742,0.00001045001,0.000006548117,0.00001853561,0.00008738059,0.0001399014,0.9825829,0.00008059396,0.01602185,0.0001473641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975604,0.00009877305,0.00005782121,0.0001262543,0.0006277936,0.000151911,0.00001094245,0.00005622475,0.001309886],"genre_scores_gemma":[0.9936146,0.0001239407,0.0005382246,0.00007960943,0.0001935085,0.00002996638,0.00003678188,0.00001259433,0.005370798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01586582,"threshold_uncertainty_score":0.4176116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006533592571320737,"score_gpt":0.2596396434866458,"score_spread":0.253106050915325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}