{"id":"W4323921148","doi":"10.14715/cmb/2022.68.9.18","title":"Estrogens desensitize MCF-7 breast cancer cells to apelin-induced autophagy and enhanced growth under estrogen starvation: a possible implication in endocrine resistance","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Biology","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Centre International de Mathématiques et Informatique de Toulouse; Sorbonne Université; Institut National de la Santé et de la Recherche Médicale","keywords":"MCF-7; Estrogen; Starvation; Autophagy; Endocrinology; Internal medicine; Endocrine system; Breast cancer; Apelin; Cancer; Biology; Hormone; Medicine; Human breast; Apoptosis; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000270845,0.0001844741,0.0003129186,0.0002366572,0.0001265855,0.00001333452,0.0001070646,0.0001084874,0.0001424042],"category_scores_gemma":[0.0000612587,0.0001774304,0.00005020709,0.0005366369,0.0001261212,0.00002224519,0.0002378641,0.0003774379,0.000007927211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001781092,"about_ca_system_score_gemma":0.0002489128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002861544,"about_ca_topic_score_gemma":0.00002532696,"domain_scores_codex":[0.998212,0.0001806243,0.0003111876,0.0005864135,0.0002386114,0.0004711402],"domain_scores_gemma":[0.9991619,0.00006446789,0.00006436418,0.0002642647,0.0001371925,0.0003077891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003482545,0.00007728644,0.0003515977,0.00004084442,0.00006337337,0.0001885065,0.00008231514,0.000009728905,0.9951444,0.001954651,0.00007183956,0.001667168],"study_design_scores_gemma":[0.002215164,0.0004236806,0.008645747,0.00003674417,0.00007336029,0.0001633836,0.0001911932,0.0002552605,0.9854169,0.001522776,0.0008057119,0.0002500123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987308,0.001746323,0.003906119,0.006056419,0.00006815897,0.0006611049,0.00006612435,0.00003291611,0.0001548624],"genre_scores_gemma":[0.9969421,0.0002266551,0.001057688,0.001138414,0.00004718046,0.0001648585,0.0001347708,0.00002900874,0.0002593402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009727468,"threshold_uncertainty_score":0.7235402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190182205281214,"score_gpt":0.3055144589308163,"score_spread":0.2936126368780042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}