{"id":"W4323921148","doi":"10.14715/cmb/2022.68.9.18","title":"Estrogens desensitize MCF-7 breast cancer cells to apelin-induced autophagy and enhanced growth under estrogen starvation: a possible implication in endocrine resistance","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Biology","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Centre International de Mathématiques et Informatique de Toulouse; Sorbonne Université; Institut National de la Santé et de la Recherche Médicale","keywords":"MCF-7; Estrogen; Starvation; Autophagy; Endocrinology; Internal medicine; Endocrine system; Breast cancer; Apelin; Cancer; Biology; Hormone; Medicine; Human breast; Apoptosis; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059613,0.0001778418,0.0003118883,0.0002150183,0.0001468662,0.000217528,0.0001242436,0.0001996652,0.001729073],"category_scores_gemma":[0.0001194758,0.00009095717,0.000284249,0.0001775282,0.0001397465,0.0001328096,0.0001954336,0.0003393071,0.0004086726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001977257,"about_ca_system_score_gemma":0.0001646406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005560152,"about_ca_topic_score_gemma":0.001044321,"domain_scores_codex":[0.9998912,0.00002195899,0.00001204859,0.00001530952,0.0000303432,0.00002911886],"domain_scores_gemma":[0.9999416,0.00001388802,0.00001208778,0.00001002148,0.000009512338,0.00001298346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003653079,0.00004174721,0.0002778754,0.00005767519,0.00000809647,0.0001707727,0.00003578021,0.00003831103,0.9966998,0.00006477821,0.00008226917,0.002157565],"study_design_scores_gemma":[0.00004011605,0.000693756,0.01742972,0.00001419478,0.00002689127,0.0008931882,0.0001623122,0.0004713547,0.9717207,0.0001068378,0.008431057,0.000009960339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902366,0.00546862,0.001032942,0.0002906822,0.00006077047,0.00002045638,0.0004915386,0.00005285231,0.00234553],"genre_scores_gemma":[0.9903931,0.00307279,0.001165999,0.0002525663,0.00002284519,0.00004769482,0.0009457716,0.00001295154,0.00408631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729073,"threshold_uncertainty_score":0.005784333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190182205281214,"score_gpt":0.3055144589308163,"score_spread":0.2936126368780042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}