{"id":"W4323923724","doi":"10.1053/j.gastro.2023.02.049","title":"A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer","year":2023,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Japan Society for the Promotion of Science; Ministry of Science and ICT, South Korea; Korea Advanced Institute of Science and Technology; National Institutes of Health; Daiichi Sankyo Foundation of Life Science; National Research Foundation of Korea; Lustgarten Foundation; Daiichi Sankyo Europe; SGH Foundation; LG Yeonam Cultural Foundation; Cold Spring Harbor Laboratory; National Cancer Institute; National Research Foundation","keywords":"Pancreatic cancer; Biology; Cancer research; Transcriptome; Basal (medicine); Metastasis; Cancer cell; Cancer; Cell biology; Endocrinology; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009229536,0.0001129038,0.0001191071,0.0001884491,0.0002549806,0.0005870126,0.0001638186,0.0002195609,0.001177337],"category_scores_gemma":[0.00008417501,0.0001890401,0.000176075,0.0002025089,0.0001708241,0.0003302342,0.0003936681,0.0007015982,0.0003596128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377341,"about_ca_system_score_gemma":0.0002131388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005659633,"about_ca_topic_score_gemma":0.001180904,"domain_scores_codex":[0.9999192,0.00000773736,0.000005102069,0.00001934789,0.0000221044,0.00002659493],"domain_scores_gemma":[0.9999411,0.000004315048,0.00001384865,0.000006957673,0.00000701334,0.00002672047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001102316,0.00002195189,0.001046302,0.00003194401,0.000007632603,0.00009455504,0.00003732319,0.0001873875,0.9952454,0.0008272871,0.0002432269,0.002146729],"study_design_scores_gemma":[0.00002898309,0.00008473246,0.02506363,0.000007411074,0.00002057831,0.0003507012,0.0002676851,0.003852157,0.9599306,0.0002918539,0.01009157,0.00001014939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922636,0.0007403746,0.003621599,0.0001876136,0.00003629561,0.000009669062,0.0003494471,0.0001189199,0.002672584],"genre_scores_gemma":[0.9955199,0.0003014172,0.0007076409,0.00005312497,0.000004943466,0.000009777007,0.0002859646,0.00002653801,0.003090641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177337,"threshold_uncertainty_score":0.003938615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433547351417293,"score_gpt":0.2642299274372625,"score_spread":0.2498944539230896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}