{"id":"W4323928821","doi":"10.1186/s13148-023-01459-z","title":"A systematic evaluation of normalization methods and probe replicability using infinium EPIC methylation data","year":2023,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Hatch (Canada)","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Normalization (sociology); Intraclass correlation; Replicate; Statistics; Pearson product-moment correlation coefficient; Percentile; Reproducibility; EPIC; Correlation; Standard deviation; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":{"n_in":0,"stratum":"aff_core","weight":5595.2375,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"medium","reason":"Evaluation of normalization pipelines and probe reliability on a methylation array; technical assay reproducibility, the polysemy trap rather than the reproducibility of research."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"This study examines technical probe replicability and normalization in a biomedical assay, not research reproducibility."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Technical evaluation of methylation-array normalization and probe reliability; assay/lab-method performance, not metaresearch reproducibility."}}}