{"id":"W4323975743","doi":"10.1101/2023.03.10.532046","title":"Predominant myosin super-relaxed state in canine myocardium with naturally occurring dilated cardiomyopathy","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Saint John Regional Hospital","funders":"Merck KGaA","keywords":"Myosin; Dilated cardiomyopathy; Contractility; Ventricle; Cardiomyopathy; MYH7; Actin; Chemistry; Internal medicine; Biology; Biophysics; Heart failure; Myosin light-chain kinase; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002926326,0.0002283179,0.0002511806,0.0006116434,0.0001761857,0.0001685468,0.0002001453,0.0003522559,0.00124266],"category_scores_gemma":[0.0002667539,0.0002161725,0.0001297222,0.0001701579,0.0004961057,0.0001923857,0.0003172933,0.0002358188,0.0001300947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001690948,"about_ca_system_score_gemma":0.00005982873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003001095,"about_ca_topic_score_gemma":0.0006896388,"domain_scores_codex":[0.9998558,0.00001712258,0.00001329279,0.00005193459,0.00002919655,0.00003259851],"domain_scores_gemma":[0.9997364,0.00003746995,0.0001254896,0.0000231762,0.00002297992,0.00005447474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008114961,0.00007497264,0.02596039,0.00009235487,0.00002191053,0.001701279,0.0001621021,0.0001103727,0.9691086,0.0001181371,0.00006220936,0.001776107],"study_design_scores_gemma":[0.00006412184,0.002758654,0.8407785,0.00002488794,0.00006893744,0.009514859,0.0004271824,0.001373047,0.1430637,0.0001472564,0.001755918,0.00002300902],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992726,0.0002275975,0.0002536841,0.00001033449,0.000004163837,0.000006108875,0.00004604821,0.000006843978,0.0001725875],"genre_scores_gemma":[0.999007,0.0001181865,0.0003408027,0.00002075004,0.000005838484,0.00001254828,0.0001875032,0.000005050132,0.0003024284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124266,"threshold_uncertainty_score":0.004157126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390184954527844,"score_gpt":0.2253671683698107,"score_spread":0.2114653188245323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}