{"id":"W4324020926","doi":"10.1177/19322968231159360","title":"Regulatory Verification by Health Canada of Content in Recombinant Human Insulin, Human Insulin Analog, and Porcine Insulin Drug Products in the Canadian Market Using Validated Pharmacopoeial Methods Over Nonvalidated Approaches","year":2023,"lang":"en","type":"article","venue":"Journal of Diabetes Science and Technology","topic":"Diabetes Management and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada","keywords":"Insulin; Human insulin; Pharmacy; Medicine; Insulin analog; Insulin pen; Drug; Diabetes mellitus; High-performance liquid chromatography; Pharmacology; Internal medicine; Chemistry; Chromatography; Endocrinology; Nursing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02746287,0.0007592765,0.0004054542,0.004131405,0.004167433,0.003358019,0.003052459,0.001749468,0.003607785],"category_scores_gemma":[0.03203509,0.0004532886,0.001031131,0.003424827,0.004293014,0.0008886521,0.001360847,0.00196114,0.000833436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02552914,"about_ca_system_score_gemma":0.1084846,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6916371,"about_ca_topic_score_gemma":0.7561604,"domain_scores_codex":[0.9461396,0.007897759,0.002691884,0.003629714,0.03776725,0.001873701],"domain_scores_gemma":[0.9374163,0.005915683,0.003953478,0.003489751,0.04791978,0.001305111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002139011,0.001001666,0.09840426,0.004364939,0.0004095973,0.001398972,0.007411048,0.001764414,0.2606282,0.03922284,0.06874379,0.5145114],"study_design_scores_gemma":[0.000296368,0.001604986,0.2508167,0.003231865,0.0006941417,0.001377238,0.002313859,0.00646796,0.216315,0.002054558,0.5144254,0.0004018775],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4056782,0.034673,0.1613513,0.02216759,0.002848967,0.01252472,0.01712346,0.002630279,0.3410025],"genre_scores_gemma":[0.7436275,0.00824273,0.2015418,0.009518445,0.0002440233,0.001496668,0.008032904,0.0004813857,0.0268145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3083629,"threshold_uncertainty_score":0.6203578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1005603709945133,"score_gpt":0.360533217230765,"score_spread":0.2599728462362517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}