{"id":"W4324028315","doi":"10.1161/circulationaha.122.063383","title":"Can Novel Myosin Inhibitors Defer Septal Reduction Therapy in HCM? At What Risk and at What Cost?","year":2023,"lang":"en","type":"letter","venue":"Circulation","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Hospital; Toronto General Hospital","funders":"","keywords":"Medicine; Internal medicine; Cardiology; Hypertrophic cardiomyopathy; Alcohol septal ablation; Cardiomyopathy; Heart failure; Obstructive cardiomyopathy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001896459,0.0007028198,0.002483986,0.0007602836,0.001815267,0.002709438,0.001149882,0.02776445,0.006005947],"category_scores_gemma":[0.01578955,0.0004278626,0.001689634,0.0005483904,0.002322615,0.002862813,0.0008128897,0.02201644,0.004107641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002565405,"about_ca_system_score_gemma":0.002330086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001936832,"about_ca_topic_score_gemma":0.003967545,"domain_scores_codex":[0.9987301,0.0004211589,0.0001782328,0.0001358486,0.0003320396,0.0002026255],"domain_scores_gemma":[0.9928006,0.004437606,0.0004111344,0.0002130386,0.0006538893,0.001483749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001629464,0.0005449117,0.009296395,0.0003938386,0.0002547795,0.04059273,0.0002131267,0.0005519481,0.0013775,0.01318866,0.8249117,0.1070449],"study_design_scores_gemma":[0.003601722,0.001568963,0.0168221,0.003527003,0.0006989515,0.05483531,0.0009972129,0.003075314,0.001195949,0.09029604,0.823061,0.000320347],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002367082,0.008580085,0.0002677256,0.9665673,0.01541586,0.00002113627,0.00005895988,0.00003151456,0.006690214],"genre_scores_gemma":[0.03064618,0.01256657,0.0009760988,0.6669446,0.2824644,0.00008609947,0.00008267008,0.00003506325,0.006198261],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02776445,"threshold_uncertainty_score":0.02009189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03469712495909054,"score_gpt":0.2655214684127077,"score_spread":0.2308243434536171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}