{"id":"W4324045235","doi":"10.1038/s41588-023-01314-0","title":"Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk","year":2023,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; NIHR Leicester Biomedical Research Centre; NIHR Nottingham Biomedical Research Centre; School of Public Health, Imperial College London; Institute of Genetics; National Health and Medical Research Council; Wellcome Trust; Cancer Research UK; BHF Centre of Research Excellence, Oxford; Biotechnology and Biological Sciences Research Council; MRC-PHE Centre for Environment and Health; Universiteit Gent; British Lung Foundation; University of Oxford; National Institutes of Health; University of Leicester; Alpha-1 Foundation; National Institute for Health and Care Research; Peking University; Brigham and Women's Hospital; British Heart Foundation; UK Research and Innovation; Universität Basel; National Cancer Institute; University of Bristol; COPD Foundation; Medical Research Council; University of Texas Health Science Center at Houston; Imperial College London; Peking University Health Science Center; Wellcome","keywords":"Phenome; Genome-wide association study; Biology; COPD; Genetic association; Gene; Disease; Genetics; Lung function; Genome; Bioinformatics; Computational biology; Single-nucleotide polymorphism; Lung; Genotype; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001920158,0.0009280368,0.002581298,0.003138792,0.0002032281,0.001113237,0.001190554,0.00115705,0.003884172],"category_scores_gemma":[0.002781722,0.0002809139,0.001718894,0.002942852,0.0004138251,0.001021457,0.0008725346,0.001878908,0.001153616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007087681,"about_ca_system_score_gemma":0.001674733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00156605,"about_ca_topic_score_gemma":0.003708107,"domain_scores_codex":[0.9994592,0.0001772913,0.00007059082,0.0000945135,0.0001506244,0.00004790525],"domain_scores_gemma":[0.9982166,0.001259636,0.0001577468,0.00004856972,0.0002475697,0.00006991066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000264047,0.00004787495,0.001027204,0.04528247,0.001965173,0.0001702812,0.00004639048,0.0005324174,0.001191394,0.003713487,0.01360667,0.9321526],"study_design_scores_gemma":[0.0001687646,0.0002714011,0.01173346,0.02823753,0.006291401,0.001833689,0.0001464165,0.0005207317,0.0009525127,0.01131628,0.9384492,0.00007861715],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001251925,0.9989617,0.0001758547,0.0002786769,0.00006537668,0.000004020896,0.00003686909,0.000007646323,0.0003446805],"genre_scores_gemma":[0.00185819,0.997059,0.0004745465,0.0002486143,0.00007195064,0.00000744459,0.00008616917,0.000002934828,0.0001911369],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003884172,"threshold_uncertainty_score":0.01299381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04291628776939022,"score_gpt":0.3508168932087169,"score_spread":0.3079006054393267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}