{"id":"W4324056768","doi":"10.3390/cells12060883","title":"Environmental Enrichment Engages Vesicular Zinc Signaling to Enhance Hippocampal Neurogenesis","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Calgary; University of Washington","keywords":"Neurogenesis; Hippocampal formation; Dentate gyrus; Hippocampus; Neuroscience; Synaptic plasticity; Biology; Neuroplasticity; Environmental enrichment; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002239756,0.0002978957,0.0002386709,0.0001798854,0.0003559274,0.00008613167,0.0004461866,0.00005769225,0.0001907221],"category_scores_gemma":[0.0001326762,0.0003018634,0.0001337479,0.0005572815,0.00005216778,0.00009662795,0.0003068149,0.0001742382,0.005282852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003849942,"about_ca_system_score_gemma":0.00001929749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001369979,"about_ca_topic_score_gemma":1.98448e-7,"domain_scores_codex":[0.9971937,0.0003250895,0.0003047179,0.000949676,0.0005818005,0.0006450508],"domain_scores_gemma":[0.9986821,0.0004874213,0.00008144294,0.0004377592,0.000006663778,0.0003046176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001782442,0.00008744905,0.0000240671,0.00001168594,0.000003052404,0.000217741,0.0001353898,0.001285066,0.9960012,0.00007520397,0.0006612407,0.001480065],"study_design_scores_gemma":[0.0001142462,0.0001885474,0.0002119653,0.000009801805,0.00001654739,0.00001512106,0.00003837384,0.0002818847,0.9899524,0.00003144509,0.008854697,0.0002850133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974239,0.00002258199,0.0005464304,0.0001299252,0.0009489885,0.0004048073,0.0000438346,0.000303906,0.0001756546],"genre_scores_gemma":[0.9962483,0.0001566454,0.0001236628,0.002459493,0.0001427716,0.00006081237,0.000002633266,0.00007418736,0.0007314911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008193457,"threshold_uncertainty_score":0.9999434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02314673089248329,"score_gpt":0.2572565133907657,"score_spread":0.2341097824982824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}