{"id":"W4324057437","doi":"10.25251/skin.7.supp.117","title":"Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in moderate to severe plaque psoriasis: 52-week efficacy by prior treatment in the phase 3 POETYK PSO-1 trial","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Medicine; Placebo; Apremilast; Psoriasis; Internal medicine; Plaque psoriasis; Tolerability; Randomized controlled trial; Clinical trial; Gastroenterology; Dermatology; Adverse effect; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002460575,0.0007567977,0.001700236,0.0001816996,0.0004043492,0.0007412328,0.0004349397,0.0007854204,0.003851606],"category_scores_gemma":[0.0008991623,0.000330273,0.001410833,0.0002158671,0.0004177544,0.0005728271,0.0002746326,0.002078494,0.0005717926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004294528,"about_ca_system_score_gemma":0.00073511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000368312,"about_ca_topic_score_gemma":0.001078511,"domain_scores_codex":[0.9993149,0.0003370925,0.00005122589,0.0001250508,0.00007362317,0.00009808988],"domain_scores_gemma":[0.9994377,0.0001142772,0.0001283139,0.00006332482,0.00003953321,0.0002167191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9235694,0.01085695,0.004694765,0.0006635776,0.001289498,0.00008109424,0.0001052842,0.0005838334,0.01507299,0.0001322309,0.002752174,0.04019832],"study_design_scores_gemma":[0.7956452,0.1715117,0.025501,0.00006487304,0.0009745329,0.0002329711,0.00002939135,0.0007903653,0.002598909,0.0002484754,0.002376462,0.00002600968],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909093,0.00311647,0.0004181471,0.0002864036,0.00008773778,0.001853859,0.000944465,0.00007698507,0.002306588],"genre_scores_gemma":[0.9932417,0.0009447039,0.0005671603,0.0005322814,0.0001325926,0.00171459,0.001373731,0.0000164071,0.001476903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003851606,"threshold_uncertainty_score":0.01301289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03048802161910544,"score_gpt":0.3025046343398302,"score_spread":0.2720166127207247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}