{"id":"W4324057674","doi":"10.25251/skin.7.supp.177","title":"Primary analysis of Phase 2 results for cemiplimab in patients with metastatic basal cell carcinoma who progressed on or were intolerant to hedgehog inhibitors","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Basal cell carcinoma; Primary (astronomy); Oncology; Hedgehog signaling pathway; Medicine; Hedgehog; Basal (medicine); Carcinoma; Internal medicine; Cancer research; Basal cell; Biology; Physics; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009373491,0.000211397,0.0006971234,0.0004830537,0.00005954818,0.000005141679,0.0002722088,0.0000542619,0.000004051243],"category_scores_gemma":[0.0005755174,0.0001088775,0.0001215118,0.0008801963,0.0001341044,0.00000347778,0.0000591343,0.0001479879,7.540348e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004630222,"about_ca_system_score_gemma":0.0001416536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207961,"about_ca_topic_score_gemma":0.00005329472,"domain_scores_codex":[0.9980432,0.0001450183,0.0008275819,0.0002149366,0.000493825,0.0002754054],"domain_scores_gemma":[0.9982826,0.0003423665,0.0005583332,0.0003039413,0.0004039756,0.0001088146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3078052,0.005864068,0.0305244,0.001677258,0.009144416,0.001895501,0.03069753,0.04553792,0.4753152,0.000006494393,0.06652167,0.0250103],"study_design_scores_gemma":[0.09890034,0.193437,0.06415873,0.00331077,0.01105556,0.0002531967,0.008954674,0.00246157,0.6066154,0.00007257587,0.009188508,0.001591672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979847,0.0002448693,0.0001818174,0.0007155677,0.000131239,0.0005436451,0.0001094586,0.000003697241,0.00008498679],"genre_scores_gemma":[0.9989849,0.00005174871,0.0002355239,0.0002724788,0.0001612694,0.00001019637,0.00009890846,0.00002607295,0.0001589155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2089049,"threshold_uncertainty_score":0.4439895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574140084279799,"score_gpt":0.2847594909094331,"score_spread":0.2690180900666351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}